适用于宽频带记录信号的锋电位检测法 .pdfVIP

学兔兔 第37卷 第3期 仪 器 仪 表 学 报 Vo1．37 No．3 2016年3月 Chinese Journa1 of Scientific Instrument Mar．2Ol6 适用于宽频带记录信号的锋电位检测法冰 王兆祥，封洲燕，余 颖，朱玉芳，郭哲杉 (浙江大学生物医学工程与仪器科学学院 生物医学工程教育部重点实验室 杭州 310027) 摘 要：为了考察深部脑刺激的高频电刺激(HFS)期间各种神经元单体的动作电位发放活动，排除电刺激诱发的群峰电位的干 扰，设计了一种窗口检测新算法，直接用于检测宽频带记录信号中的锋电位。并且，利用仿真数据和大鼠海马CA1区实验记录 数据验证此算法的有效性。结果表明，新算法的锋电位检出率显著大于常规阈值法，而误检率则显著小于闽值法。该算法对于 高频刺激期间的仿真数据的锋电位检出率可达95％，误检率则仅为4％；对于7只大鼠的顺向高频刺激实验记录数据的平均锋 电位检出率为88±1．4％，而误检率为4．6±1．1％。总之，新窗口法可以正确检测高频刺激期间的锋电位，用于研究各种神 经元单体在电刺激期间的不同响应活动，为深入揭示深部脑刺激的神经网络机制提供了有用的新工具。 关键词：高频电刺激；锋电位检测；窗口法；阈值法；信噪比 中图分类号：TH782 R318 文献标识码：A 国家标准学科分类代码：316．61 Spike potential detection method for broadband-frequency recording signals Wang Zhaoxiang，Feng Zhouyan，Yu Ying，Zhu Yufang，Guo Zheshan (College of Biomedical Engineering and Instrumentation Science，Key Laboratory of Biomedical Engineering of Min~try of Education，Zhejiang University，Hangzhou 310027，China) Abstract：To investigate the activity of various single neurons during the periods of hi gh frequency stimulation(HFS)of deep brain stimulation(DBS)and eliminate the interferences of the population spikes evoked by the stimulation，a new algorithm based on window detection was designed and used to detect the spikes in broadband—frequency recording signals directly．Both simulation data and the ex· periment data recorded from the rat hippocampal CA1 region were used to verify the effectiveness of the algorithm．The results show that the new algorithm has significantly higher detection ratio and lower false positive ratio than conventional threshold method．For the simu— lation data during the HFS period，the spike detection ratio of the new algorithm is up to 95％，and the false posit