氧化应激与阻塞性睡眠呼吸暂停低通气综合征的研究进展.pdf

．综述． 氧化应激与阻塞性睡眠呼吸暂停低通气 综合征的研究进展 冯砍平芬 【摘要】阻塞性睡眠呼吸暂停低通气综合征(()SHAS)是多种伞身疾病的独立危险因素。OSHAS 可导致慢性间歇性低氧、睡眠片段、睡眠结构紊乱和神经调节功能失衡。卜述病理生理改变可引起体内 活性氧增多，从而导致氧化应激。也有很多证据证明OSHAS患者体内存在氧化应激。氧化应激与各系 统疾病密切相关。故氧化应激有可能在OSAHS各种并发症的发生发展中起着重要的作用。 【关键词】阻塞性睡眠呼吸暂停低通气综合征；氧化应激；活性氧 Studieson betweenoxidativestressandobstructive relationship sleep FENG apnea-hypopneasyndrome Xin’。PIN(；Fen．’DepartmentMedic。ine，theAffiliated Hebei ofRespiratory Hospitalof University． 071000，China Baoding author：PINGFen，Email：加ngfen03@yahoo．corn．册 Corresponding Obstructive the [Abstract] apnea—hypopneasyndrome(OSAHS)isdangerous sleep independent factorin kindsof diseases．OSAHScaninducechronicintermittent many systematic of hypoxia，disorder the andstructure．disorder0fnerve above sleepfragmentations regulationfunction．Theall cancausetheincreaseinreactive inhuman pathophysiologicalchanges oxygenspecies induce body，also theoxidativestressinhuman evidenceshaveshownthatoxidativestressexistedin body．Many patient with()SAHS．Oxidativestresshaveaclose with diseases．Oxidativestress relationshipmanysystemic an roleinallkindsof in()SAHS． manyplay important complications [Keywords]()bstructivesleepapnea—hypopneasyndrome；Oxidativestress；Reactiveoxygenspecies 阻塞性睡眠呼吸暂停低通气综合征 种类型。OSAHS的诊断主要根据病史、体征和多 (obstructive sleepapnea—hypopneasyndrome。导睡眠图(PSG)监测的结果，并根据睡眠呼吸暂