乌司他丁在治疗除胰腺炎外的临床应用进展.pdfVIP

药物与临床 Drugs and Clinic 乌司他丁在治疗除胰腺炎外的临床应用进展 1 2 3 1 *3 叶江浩 ，张军安 ，焦海胜 ，虞和永 ，周素琴 1.浙江大学医学院附属第四医院，322000 ；2. 甘肃省武威肿瘤医院, 733000 ；3. 兰州大学第二医院，730000 [摘要] 目的：为乌司他丁在治疗胰腺炎外的临床应用提供文献参考。方法：查阅国内外近年来的相关文献，综述了乌司他丁在 治疗胰腺炎以外的临床应用进展。结果与结论：乌司他丁目前已被应用于围手术期、抗休克、脓毒症、有机磷中毒、重型颅脑损 伤、心肺复苏、肝脏疾病和体外循环的治疗。因此随着临床方面的不断深入研究，乌司他丁的应用前景将会更加广阔。 [关键词] 乌司他丁；临床应用 [中图分类号] R979.1　　[文献标识码]　A　　[文章编号]　1672-2809(2015)16-0021-04 The Progress of Clinical Application of Ulinastatin in the Treatment of Diseases Except for Pancreatitis 1 2 3 1 *3 YE Jiang-hao , ZHANG Jun-an , JIAO Hai-sheng , YU He-yong , ZHOU Su-qin 1.The Fourth Affiliated Hospital of Zhejiang University of Medicine 322000; 2.Gansu Wuwei Tumour Hospital,733000; 3.Lanzhou University Second Hospital, 73000 [Abstract] Objective: To provide the reference for the clinical application of ulinastatin in the treatment of diseases except for pancreatitis. Method: we consulted the relevant literature at domestic and abroad in recent years, and reviewed ulinastatin clinical application in the treatment of diseases except for pancreatitis. Result and Conclusion: Ulinastatin has now been widely applied to the perioperative period, anti-shock, sepsis therapy, organophosphate poisoning, severe brain injury, cardiopulmonary resuscitation, liver disease and extracorporeal circulation. Therefore, with the deepening of clinical research, applications of Ulinastatin will be broader. [Key words] ulinastatin; clinical application 1 前言 急性胰腺炎的治疗药物，在日本广泛使用。乌司 1909 年B e u e r 和R e i c h 首次报道了人体尿液 他丁。随着临床实践的发展，乌司他丁在胰腺炎 中存在一种胰蛋白酶抑制剂。最早商业化的产品 之外的应用研究也取得了重要的进展。本文将对 就是乌司他丁，是从成年男性尿液中提取出来的 乌司他丁在胰腺炎外的其他临床研究进展作一综 一种糖蛋白，