Application of a New Processing Method to Post-LDL-apheresis Data英文文献资料.docVIP

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Application of a New Processing Method to Post-LDL-apheresis Data英文文献资料.doc

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Application of a New Processing Method to Post-LDL-apheresis Data英文文献资料

JournalofTheoreticalMedicine,2002Vol.4(3),pp.191–196 ApplicationofaNewProcessingMethodtoPost-LDL-apheresis Data FRANCOCORSINIa,ARRIGOF.G.CICEROb,*,ANTONIAGIANNUZZIcandANTONIOGADDIb aMedicalandSurgicalPaediatricSciencesComplexUnit,UniversityofBologna,Italy; bClinicalMedicineandAppliedBiotechnologyDepartment “D.Campanacci”,Atherosclerosiscentre“G.Descovich”,UniversityofBologna,Orsola-MalpighiHospital,ViaMassarenti9,40138Bologna,Italy; cClinicalMedicineandAppliedBiotechnologyDepartment“D.Campanacci”,UniversityofBologna,Italy (Received18October2001;In?nalform29July2002) Our aim was to elaborate a method to optimise treatment intervals for the individual low-density lipoprotein(LDL)-apheresistreatedpatients.Aftereachtreatment,plasmaLDLconcentrationsshowa time-relatedincreasewithadecreasingspeeduntilamaximumlevel.Wesearchedtointerpretthepost- LDL-apheresisexperimentaldatatrendasthephysicalprocessthatproducestheobservedcurve,sothat the?ttingpresupposedtheoreticalfunctionisadirectconsequenceofthephysicprocess,becauseto establishthebettertime.Applyingtheproposed?ttingmethodtoasuccessionof15samplesobtained fromthemeanofsixplasmapheresisexecutedon?vedifferentsubjects,smallestimatestandarderror (5mg/dl)andrelativeerror(1.7%)withadispersionevidentlyrelatedtotheexperimentalerrorwere observed.Obviously,applyingthesamemethodtoasinglecase,thedispersionismoremarked(relative error,5%),withaSEof10–13mg/dl,eventhoughtheaspectofacasualphenomenonisconserved. OurphysicalinterpretationappearstobeapracticalmodeltopredicttheLDL-reboundkineticofthe singlepatient. Keywords: Fittingmethod;LDL-apheresis;LDLkinetic;Mathematicalmodel INTRODUCTION extracorporeal LDL precipitation (Eisenhauer et al., 1987;Seideletal.,1991)anddextranesulfateadsorption (Homma et al., 1986; Mabuchi et al., 1987). All the techniqueshavedemonstratedtheirsafetyandlong-term ef?cacy on coronary and extracoronary artery disease (Richter et al., 1996; Thiery Seidel, 1998) treatment. Besides the LDL concentration decr