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Angiogenesis From Chronic Liver Inflammation to Hepatocellular Carcinoma英文文献资料.doc

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Angiogenesis From Chronic Liver Inflammation to Hepatocellular Carcinoma英文文献资料

HindawiPublishingCorporation JournalofOncology Volume2010,ArticleID272170,7pages doi:10.1155/2010/272170 ReviewArticle Angiogenesis:FromChronicLiverIn?ammationto HepatocellularCarcinoma PalomaSanz-Cameno,1,2,3Mar′?aTrapero-Maruga′n,2,3Mar′?aChaparro, 2,3 EvanAnthonyJones, 2andRicardoMoreno-Otero 2,3 1 LaboratoryofInvestigation,MolecularBiologyUnit,HospitalUniversitariodelaPrincesa,UniversidadAut′onomadeMadrid, 28006-Madrid,Spain 2 3 HepatologyUnit,HospitalUniversitariodelaPrincesa,UniversidadAut′onomadeMadrid,28006Madrid,Spain CIBERehd,InstitutodeSaludCarlosIII,28006Madrid,Spain CorrespondenceshouldbeaddressedtoRicardoMoreno-Otero,rmoreno.hlpr@ Received18November2009;Revised24February2010;Accepted16March2010 AcademicEditor:ArkadiuszDudek Copyright?2010PalomaSanz-Camenoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Recently,newinformationrelatingtothepotentialrelevanceofchronichepaticin?ammationtothedevelopmentandprogression ofhepatocellularcarcinoma(HCC)hasbeengenerated.Persistenthepatocellularinjury altersthehomeostaticbalancewithin theliver;deregulationoftheexpressionoffactorsinvolvedinwoundhealingmayleadtotheevolutionofdysplasticlesionsinto transformednodules.Progressionofsuchnodulesdependsdirectlyonthedevelopmentandorganizationofavascularnetwork, whichprovidesthenutritionalandoxygenrequirementstoanexpandingnodularmass.Angiogenicstimulationpromotesintense structural and functional changes in liver architecture and physiology, in particular, it facilitates transformation of dysplasia to nodular lesions with carcinogenic potential. HCC depends on the growth and spreading of vessels throughout the tumor. Becausethesevascularphenomenacorrelatewithdiseaseprogressionandprognosis,therapeuticstrategiesarebeingdeveloped thatfocusonprecludingvascularexpansioninthesetumors.Accordingly,anin-depthstudyoffactorsthatpromoteands