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Angiogenic Factor Expression in Hepatic Cirrhosis英文文献资料.doc

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Angiogenic Factor Expression in Hepatic Cirrhosis英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2007,ArticleID67187,4pages doi:10.1155/2007/67187 ClinicalStudy AngiogenicFactorExpressioninHepaticCirrhosis AlexandraGiatromanolaki,1StamatiaKotsiou,2MichaelI.Koukourakis,3andEfthimiosSivridis1 1 2 DepartmentofPathology,DemocritusUniversityofThraceMedicalSchool,P.O.Box12,68100Alexandroupolis,Greece FirstDepartmentofMedicine,DemocritusUniversityofThraceMedicalSchool,P.O.Box12, 68100Alexandroupolis,Greece 3 DepartmentofRadiotherapy/Oncology,DemocritusUniversityofThraceMedicalSchool, P.O.Box12,68100Alexandroupolis,Greece Received14October2006;Revised12December2006;Accepted12December2006 Thepathogenesisof?brosisinhepaticcirrhosisremainsobscure.Thisstudyexaminestheeventualroleofangiogenicfactorsinthe ?broticprocess.Aseriesof55cirrhoticliverswasstudiedfortheproliferationstateof?broblasts,andtheexpressionofvascular endothelialgrowthfactor(VEGF),thymidinephosphorylase(TP)andthebasicandacidic?broblastgrowthfactor(bFGF,aFGF) inboth?broblastsandhepaticcells.Theangiogenicand/or?brogenicfactorsVEGF,TP,bFGF,andaFGFwereclearlyexpressed inregenerativehepatocytes,butnotin?broblastsofdi?usehepatic?brosis.Theimmunohistochemical?ndingssuggestthatan- giogenicfactorsandfactorspromotingoxidativestress(i.e.,TP)producedbyhepatocytesmaycontributetothedevelopmentof ?brousbandsinhepaticcirrhosis. Copyright?2007AlexandraGiatromanolakietal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. 1. INTRODUCTION 2. MATERIALSANDMETHODS Formalin-?xedpara?n-embeddedtissuesfrombiopsiesof 55patientswithfullydevelopedmicronodularcirrhosiswere retrievedfromthearchivesoftheDepartmentofPathology, Democritus University of Thrace Medical School, Alexan- droupolis,Greece.Allcaseswereofaposthepatiticetiology forthepatientshavingalong-standinghistoryofchronicvi- ralhepatitisBwithahistologicalactivityindexrangi