Cerium (IV) Ammonium Nitrate (CAN) Mediated Reactions IV. A Highly Efficient Synthesis of N,N’-Diarylsubstituted Formamidines in Water at Ambient Temperature英文文献资料.docVIP

Green and Sustainable Chemistry , 2011, 1, 92-97 doi:10.4236/gsc.2011.13015 Published Online August 2011 (http://www.SciRP.org/journal/gsc) Cerium (IV) Ammonium Nitrate (CAN) Mediated ReactionsIV. A Highly Efficient Synthesis of N,N’-Diarylsubstituted Formamidines in Water at Ambient Temperature Kamal Usef Sadek , Abdulaziz Alnajjar , Ramadan Ahmed Mekheimer , 1* 2 1,3 1 1 Nasr Kamel Mohamed Chemistry Department, Faculty of Science, El-Minia University, El-Minia 61519, AR Egypt , Haney A. Mohamed 1 2 Applied Science Department, College of Technological Studies, Public Authority of applied Education and training, Safat Kuwait Current address: Department of Chemistry, Faculty of Science for Girls, King Abdul-Aziz University, 3 Jeddah, Kingdom of Saudi Arabia E-mail: Received March 29, 2011; revised May 9, 2011; accepted May 23, 2011 * kusadek@ Abstract A green, simple and highly efficient synthesis of N,N-diarylsubstituted formamidines has been developed employs reaction of triethylorthoformate (TEO) with aromatic amines catalyzed by cerium (IV) ammonium nitrate (CAN) in water at ambient temperature. This method offers the advantages of proceeding under envi- ronmentally friendly technique with high yields and simplicity either in conducting the reaction or handling the products. Keywords: CAN, Triethylorthoformate, Aromatic Amines, Water, Ambient Temperature 1. Introduction Although the reduction of carbodiimides with sodium borohydride in isopropanol perform a convenient syn- thetic method of the corresponding formamidines [20] but this protocol suffers from the use of toxic organic solvents either in conducting the reaction or working-up the product. The exchange of N,N-dimethylformami- dines or acetamidines by a variety of amine