Controllable Assembly of Hydrophobic Superparamagnetic Iron Oxide Nanoparticle with mPEG-PLA Copolymer and Its Effect on MR Transverse Relaxation Rate英文文献资料.docVIP

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Controllable Assembly of Hydrophobic Superparamagnetic Iron Oxide Nanoparticle with mPEG-PLA Copolymer and Its Effect on MR Transverse Relaxation Rate英文文献资料.doc

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Controllable Assembly of Hydrophobic Superparamagnetic Iron Oxide Nanoparticle with mPEG-PLA Copolymer and Its Effect on MR Transverse Relaxation Rate英文文献资料

HindawiPublishingCorporation JournalofNanomaterials Volume2011,ArticleID152524,7pages doi:10.1155/2011/152524 ResearchArticle ControllableAssemblyofHydrophobicSuperparamagnetic IronOxideNanoparticlewithmPEG-PLACopolymerandIts EffectonMRTransverseRelaxationRate XuanXieandChunfuZhang Med-XResearchInstitute,ShanghaiJiaoTongUniversity,Shanghai200030,China CorrespondenceshouldbeaddressedtoChunfuZhang,cfzhang@ Received2May2010;Revised14July2010;Accepted15August2010 AcademicEditor:WilliamW.Yu Copyright?2011X.XieandC.Zhang. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Assembly of individual superparamagnetic iron oxide nanoparticles (SPION) into cluster is an e?ective way to prepare MRI contrastagentwithhighrelaxivity.Inthisstudy,wefabricatedSPIONclusterswithdi?erentsizesandcon?gurationsbyassemblyof amphiphilicmPEG-PLAcopolymerwithhydrophobicSPIONinaqueoussolution.Theevolutionofclustersizeandcon?guration withtheamountofcopolymerandthee?ectofclustersizeonthetransverserelaxivitywasstudied.T2relaxationratesofclusters withdi?erentsizesatironconcentrationof0.1mMwerecomparedwiththetheoreticalpredictions.Wefoundthattherelative amountofcopolymer/SPIONwascrucialfortheformationofSPIONcluster.ThetransverserelaxivityofthecondenseSPION clusters(CSC)wassize-dependent.TheexperimentallymeasuredT2relaxationratesoftheclusterswerelowerthanthetheoretical predictions.Inmotionalaverageregime(MAR)region,T2relaxationratesweremoreconsistentwiththetheoreticalvalueswhen transmissionelectronmicroscope(TEM)evaluatedsizewasused.Therefore,forfabricationofSPIONclusterswithassemblyof mPEG-PLAandhydrophobicSPION,delicatebalancebetweentheamountofcopolymerandSPIONshouldbepursued,andfor comparisonofexperimentalT2relaxationratewiththeoreticalpredictions,TEMevaluatedsizewasmoresuitable. 1.Introduction extensively explored for MR molecular imaging [2, 3]. H