Correct Assignment of Homology is Crucial When Genomics Meets Molecular Evolution英文文献资料.docVIP

ComparativeandFunctionalGenomics CompFunctGenom2002;3 :484–486. PublishedonlineinWileyInterScience().DOI:10.1002/cfg.215 Feature MeetingReview:IntelligentSystemsfor MolecularBiology2002(ISMB02) 3–7 August2002,ShawConferenceCentre,Edmonton,Canada K.CaraWoodwark* Biomolecular Sciences, UMIST,Manchester M601QD,UK *Correspondence to: K.CaraWoodwark, Biomolecular Sciences, UMIST,Manchester M601QD,UK. E-mail: Cara.Woodwark@ Copyright ?2002 John Wiley Sons, Ltd. Abstract This report pro?les the keynote talks given at ISMB02 in Edmonton, Canada, by MichaelAshburner, BarryHonig,IsidoreRigoutsos,FordDoolittle,StephenAltschul, Terry Gaasterland, John Reinitz, and the Overton Prize winner, David Baker. Keywords: gene ontologies; electrostatics; pattern discovery; phylogenetic trees; Received: 8October 2002 Accepted: 8October 2002 sequence searchalgorithms; mousegeneanalysis;spatialexpressionpatterns; protein structure prediction Introduction formed a common undercurrent in many subse- quent talks. As ISMB01 in Copenhagen had been voted an Barry Honig (Columbia University) gaveafas- overwhelming success,Edmontonhadmuchtolive cinating talk on how we can greatly increase upto.The coldanddamp weather, combined with our understanding of protein function by explain- jetlagfortheEuropean contingent, triedtodampen ing protein–protein, protein–DNA and even pro- spiritsbuttonoavail,andaveryfullandinteresting tein–membrane interactions in terms of electro- conference was enjoyed by all. statics.Wemayknowthestructureofaproteinbut Only the keynote talks are reported here, as this will not necessarily show the position of the the abstracts of all the posters are freely available functional site; however, once the electrostatics of onlineat:/poster.html and themoleculearemodelled,thefunctionalsiteoften thoseofthepapersareavailableat:http://bioinfor- becomes obvious. He also introduced one of the /content/vol18/suppl 1/ index.shtml otherunderlying themes ofthecon