年产1亿袋小儿感冒颗粒.docx

摘 要颗粒剂是指将药物与适宜的辅料混合制成的具有一定粒度的干燥粒状制剂。主要用于口服，可直接吞服或冲入水中口服。近几年，颗粒剂在保健和制药领域获得了长足而快速的发展，已成为口服固体制剂最主要的剂型之一。20多年来，全球批准的新药中，颗粒剂型呈上升趋势。随着药业的发展，颗粒剂具有的患者喜爱、研发效率高和生产成本低的优势获得更多消费者的认可。与其他剂型性比，颗粒剂优势比较明显。小儿感冒颗粒车间工艺设计是按照《中华人民共和国药典》、《药品生产质量管理规范》等多种规范和标准，通过Internet搜索与查询相关资料，收集大量资料和数据，在老师的指导下进行的。设计任务为年产1亿袋的小儿感冒颗粒剂车间工艺设计，根据年生产总量计算每天每小时的工作量，以此为基础结合工艺流程进行设备选型。根据设备尺寸和台数设计厂房的平面布置，并布置净化系统。设计说明书综述了小儿感冒颗粒的药理作用，小儿感冒颗粒的生产工艺设计和设备选型。关键词：颗粒剂;小儿感冒;车间工艺设计AbstractGranule is the drug and dry granular formulation has a certain size into the appropriate excipients mixed.Mainly used for oral, direct swallow oral or into the water. Recent years,Granules obtained great and rapid development in health care and pharmaceutical fields,Has become one of the most important forms of oral solid preparation.Over the past 20 years,New drugs approved in the world,Granule is on the rise. With the development of pharmaceutical,Granule has patients love, R D high efficiency and low production cost advantage of more consumer recognition.And other forms of sex ratio, granule has obvious advantages. Xiaoer Ganmao Keli workshop design is in accordance with the Ch.P and GMP and other standards,Through the search Internet and query information, collect a lot of information and data, in under the guidance of the teacher. This design task for Xiaoer Ganmao Keli workshop design with an annual output of 100000000 bags,According to the annual production volume of the workload of every hour of every day, which is combined with the process of selection of equipment.According to the layout of equipment size and the number of plant design, and the layout of purification system.The design specification of the pharmacological effect of Xiaoer Ganmao Keli, technological design and equipment selection of Xiaoer Ganmao keli.Keywords:Granules;Common cold in children;the design of workshop第一章 文献综述1.1 感冒疾病概述感冒是人类最普遍的多发疾病，有着极多的患病人群。有关资料显示，绝大部分人群每年感冒患病率在1-2次以上，故该疾病的基础人群数以亿计。中药感冒药的抗病毒效果远远超过西药，成为治疗该疾病的首选药物。近几年非典、禽流感的肆虐，使感冒类药的销量直线上升,成为市场上大卖点。感