腹腔镜CO2气腹对肿瘤种植转移影响的研究进展.docVIP

　　腹腔镜CO2气腹对肿瘤种植转移影响的研究进展 【摘要】 目的：腹腔镜在肿瘤手术中的 应用 已逐步开展，成为肿瘤外科 研究 的热点之一。CO2气腹促进肿瘤种植转移一直受到广泛关注，其机制涉及CO2气腹压力、局部微酸环境、机体免疫和肿瘤细胞粘附性能改变等多方面因素。现对近年腹腔镜CO2气腹对肿瘤种植转移 影响 的研究进展作一综述。 【关键词】 肿瘤种植；肿瘤转移；腹腔镜术；二氧化碳气腹；综述 ［７］ Volz J,Koster S,Schaeff B,et al.Laparoscopic surgery:the effects of insufflation gas on tumorinduced lethality in unde mice［Ｊ］.Am J Obstet Gynecol,1998,178(4):793795. ［８］ Yavuz Y,Ronning K,Lyng O,et al.Effect of carbon dioxide pneumoperitoneum on tissue blood flo,rectus abdominis,and diaphragm muscles［Ｊ］.Surg Endosc,2003,17(10):16321635. ［９］ Ishida H,Hashimoto D,Nakada H,et al.Increased insufflation pressure enhances the development of liver metastasis in a mouse laparoscopy model:possible mechanisms［Ｊ］.Surg Endosc,2002,16(2):331335. ［１０］ Volz J,Koster S,Spacek Z,et al.Characteristic alterations of the peritoneum after carbon dioxide pneumoperitoneum［Ｊ］.Surg Endosc,1999,13(16):611614. ［１１］ Jacobi CA,Sabat R,Bohm B,et al.Pneumoperitoneum ulates groalignant colonic cells［Ｊ］.Surgery,1997,121(1):7278. ［１２］ Kuntz C,A,Hackam DJ,Baker J,et al.Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon dioxide［Ｊ］.Am Surg,1997,226(2):179190. ［１５］ ,et al. The effects of duration of CO2 insufflation and irrigation on peritoneal microcirculation assessed by free radical scavengers and total glutathion levels during operative laparoscopy［Ｊ］.J Am Assoc Gynecol Laparosc,1998,5(2):129133. ［１７］ Takeuchi I,Ishida H,Mori T,et al.parison of the effects of gasless procedure,CO2 pneumoperitoneum,and laparotomy on splenic and hepatic natural killer activity in a rat model［Ｊ］.Surg Endosc,2004,18(2):255260. ［１８］ Mohri Y.Prognostic significance of Ecadherin expression in human colorectal cancer tissue［Ｊ］.Surg Today,1997,27(7):606612. ［１９］ Maeda K,Kang SM,Saolecule1 and prognosis in colorectal cancer［Ｊ］.Oncol Rep,2002,9(3):511514. ［２０］ 陈冰，黄文斌.CD44V6在结直肠癌中的表达及其临床意义［Ｊ］.世界华人消化杂志，2002，10（4）：471472. ［２１］ Kim ZG,Mehl C,Lorenz M