A Companion Cell–Dominant and Developmentally Regulated H3K4 Demethylase Controls Flowering Time in Arabidopsis via the Repression of FLC Expression 英文参考文献.docVIP

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A Companion Cell–Dominant and Developmentally Regulated H3K4 Demethylase Controls Flowering Time in Arabidopsis via the Repression of FLC Expression 英文参考文献.doc

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A Companion Cell–Dominant and Developmentally Regulated H3K4 Demethylase Controls Flowering Time in Arabidopsis via the Repression of FLC Expression 英文参考文献

ACompanionCell–DominantandDevelopmentally RegulatedH3K4DemethylaseControlsFloweringTime inArabidopsisviatheRepressionofFLCExpression HongchunYang1,2,3,ZhifuHan2,YingCao2,3,DiFan2,HongLi2,HuixianMo2,3,YiFeng2,LeiLiu3, ZhengWang2,4,YanlingYue2,SujuanCui3,SheChen2,JijieChai2,LigengMa2,3,4* 1StateKeyLaboratoryofPlantPhysiologyandBiochemistry,CollegeofBiologicalSciences,ChinaAgriculturalUniversity,Beijing,China,2NationalInstituteofBiological Sciences,Beijing,China,3HebeiKeyLaboratoryofMolecularCellBiology,CollegeofBiologicalSciences,HebeiNormalUniversity,Shijiazhuang,China,4CollegeofLife Sciences,CapitalNormalUniversity,Beijing,China Abstract Floweringtimereliesontheintegrationofintrinsicdevelopmentalcuesandenvironmentalsignals.FLCanditsdownstream targetFTarekeyplayersinthefloraltransitioninArabidopsis.Here,wecharacterizedtheexpressionpatternandfunctionof JMJ18,anovelJmjCdomain-containinghistoneH3K4demethylasegeneinArabidopsis.JMJ18wasdominantlyexpressedin companion cells; its temporal expression pattern was negatively and positively correlated with that of FLC and FT, respectively,duringvegetativedevelopment.MutationsinJMJ18resultedinaweaklate-floweringphenotype,whileJMJ18 overexpressors exhibited an obvious early-flowering phenotype. JMJ18 displayed demethylase activity toward H3K4me3 andH3K4me2,andboundFLCchromatindirectly.ThelevelsofH3K4me3andH3K4me2inchromatinsofFLCcladegenes andtheexpressionofFLCcladegeneswerereduced,whereasFTexpressionwasinducedandtheproteinexpressionofFT increasedinJMJ18overexpressorlines.Theearly-floweringphenotypecausedbytheoverexpressionofJMJ18wasmainly dependentonthefunctionalFT.Ourfindingssuggestthatthecompanioncell–dominantanddevelopmentallyregulated JMJ18 binds directly to the FLC locus, reducing the level of H3K4 methylation in FLC chromatin and repressing the expressionofFLC,therebypromotingtheexpressionofFTincompanioncellstostimulateflowering. Citation:YangH,HanZ,CaoY,FanD,LiH,etal.(2012)ACompanionCell–DominantandDevelopmentallyRegulate