A Comparative Computer Simulation of Dendritic Morphology 英文参考文献.docVIP

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A Comparative Computer Simulation of Dendritic Morphology 英文参考文献.doc

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A Comparative Computer Simulation of Dendritic Morphology 英文参考文献

AComparativeComputerSimulationofDendritic Morphology DuncanE.Donohue,GiorgioA.Ascoli* NeuroscienceProgramandKrasnowInstituteforAdvancedStudy,GeorgeMasonUniversity,Fairfax,Virginia,UnitedStatesofAmerica Abstract Computational modeling of neuronal morphology is a powerful tool for understanding developmental processes and structure-function relationships. We present a multifaceted approach based on stochastic sampling of morphological measures from digital reconstructions of real cells. We examined how dendritic elongation, branching, and taper are controlledbythreemorphometricdeterminants:BranchOrder,Radius,andPathDistancefromthesoma.Virtualdendrites were simulated starting from 3,715 neuronal trees reconstructed in 16 different laboratories, including morphological classesasdiverseasspinalmotoneuronsanddentategranulecells.Severalemergentmorphometricswereusedtocompare realandvirtualtrees.RelatingmodelparameterstoBranchOrderbestconstrainedthenumberofterminationsformost morphologicalclasses,exceptpyramidalcellapicaltrees,whichwerebetterdescribedbyadependenceonPathDistance. In contrast, bifurcation asymmetry was best constrained by Radius for apical, but Path Distance for basal trees. All determinants showed similar performance in capturing total surface area, while surface area asymmetry was best determinedbyPathDistance.Groupingbyothercharacteristics,suchassize,asymmetry,arborizations,oranimalspecies, showed smaller differences than observed between apical and basal, pointing to the biological importance of this separation. Hybrid models using combinations of the determinants confirmed these trends and allowed a detailed characterization of morphological relations. The differential findings between morphological groups suggest different underlyingdevelopmentalmechanisms.Bycomparingtheeffectsofseveralmorphometricdeterminantsonthesimulation of different neuronal classes, this approach sheds light on possible growth mechanism variations responsible for the observedneur