A Computational Study on the Role of Gap Junctions and Rod Ih Conductance in the Enhancement of the Dynamic Range of the Retina 英文参考文献.docVIP
- 1、本文档共7页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
A Computational Study on the Role of Gap Junctions and Rod Ih Conductance in the Enhancement of the Dynamic Range of the Retina 英文参考文献
AComputationalStudyontheRoleofGapJunctionsand
RodIhConductanceintheEnhancementoftheDynamic
RangeoftheRetina
RodrigoPublio1*,RodrigoF.Oliveira2,AntonioC.Roque3
1ComputationalNeuroscienceUnit,OkinawaInstituteofScienceandTechnology,Okinawa,Japan,2ComputationalandExperimentalNeuroplasticityLaboratory,The
KrasnowInstituteforAdvancedStudy,GeorgeMasonUniversity,Fairfax,Virginia,UnitedStatesofAmerica,3DepartmentofPhysicsandMathematics,FFCLRP,University
ofSa?o Paulo,Ribeira?o Preto,Brazil
Abstract
Recent works suggest that one of the roles of gap junctions in sensory systems is to enhance their dynamic range by
avoidingearlysaturationinthefirstprocessingstages.Inthiswork,weuseaminimalconductance-basedmodeloftheON
rodpathwaysinthevertebrateretinatostudytheeffectsofelectricalsynapticcouplingviagapjunctionsamongrodsand
amongAIIamacrinecellsonthedynamicrangeoftheretina.Themodelisalsousedtostudytheeffectsofthemaximum
conductance of rod hyperpolarization activated current Ih on the dynamic range of the retina, allowing a study of the
interrelations between this intrinsic membrane parameter with those two retina connectivity characteristics. Our results
show that for realistic values of Ih conductance the dynamic range is enhanced by rod-rod coupling, and that AII-AII
couplingislessrelevanttodynamicrangeamplificationincomparisonwithreceptorcoupling.Furthermore,aplotofthe
retinaoutput response versusinput intensityfor the optimal parameter configuration is well fitted by apower law with
exponent *0:5. The results are consistent with predictions of more theoretical works and suggest that the earliest
expression of gap junctions along the rod pathways, together with appropriate values of rod Ih conductance, has the
highestimpactonvertebrateretinadynamicrangeenhancement.
Citation: Publio R, Oliveira RF, Roque AC (2009) A Computational Study on the Role of Gap Junctions and Rod Ih Conductance in the Enhancement of the
DynamicRangeoftheRetina.PLoSONE4(9):e6970.doi:10.1371/journal.pone.
您可能关注的文档
- 8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis 英文参考文献.doc
- 8q24 Cancer Risk Allele Associated with Major Metastatic Risk in Inflammatory Breast Cancer 英文参考文献.doc
- 9-Genes Reinforce the Phylogeny of Holometabola and Yield Alternate Views on the Phylogenetic Placement of Strepsiptera 英文参考文献.doc
- 6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-AlanineD-Alanine Ligase 英文参考文献.doc
- A 21-Year-Old Pregnant Woman with Hypertension and Proteinuria 英文参考文献.doc
- A 10-Year Analysis of the Effects of Media Coverage of Regulatory Warnings on Antidepressant Use in The Netherlands and UK 英文参考文献.doc
- 92-Gene Molecular Profiling in Identification of Cancer Origin A Retrospective Study in Chinese Population and Performance within Different Subgroups 英文参考文献.doc
- A 2nd Generation Linkage Map of Heterobasidion annosum s.l. Based on In Silico Anchoring of AFLP Markers 英文参考文献.doc
- A 14-Item Mediterranean Diet Assessment Tool and Obesity Indexes among High-Risk Subjects The PREDIMED Trial 英文参考文献.doc
- 7-Valent Pneumococcal Conjugate Vaccination in England and Wales Is It Still Beneficial Despite High Levels of Serotype Replacement 英文参考文献.doc
- 大学生职业规划大赛《新闻学专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《应用统计学专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《音乐学专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《中医学专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《信息管理与信息系统专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《汽车服务工程专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《水产养殖学专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《市场营销专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《音乐表演专业》生涯发展展示PPT.pptx
- 大学生职业规划大赛《音乐学专业》生涯发展展示PPT.pptx
文档评论(0)