A Model Framework to Estimate Impact and Cost of Genetics-Based Sterile Insect Methods for Dengue Vector Control 英文参考文献.docVIP

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A Model Framework to Estimate Impact and Cost of Genetics-Based Sterile Insect Methods for Dengue Vector Control 英文参考文献.doc

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A Model Framework to Estimate Impact and Cost of Genetics-Based Sterile Insect Methods for Dengue Vector Control 英文参考文献

AModelFrameworktoEstimateImpactandCostof Genetics-BasedSterileInsectMethodsforDengueVector Control NinaAlphey1,2*,LukeAlphey2,3,MichaelB.Bonsall1 1MathematicalEcologyResearchGroup,DepartmentofZoology,UniversityofOxford,Oxford,UnitedKingdom,2Oxitec,Limited,Oxford,UnitedKingdom,3Department ofZoology,UniversityofOxford,Oxford,UnitedKingdom Abstract Vector-borne diseases impose enormous health and economic burdens and additional methods to control vector populationsareclearlyneeded.TheSterileInsectTechnique(SIT)hasbeensuccessfulagainstagriculturalpests,butisnotin large-scaleuseforsuppressingoreliminatingmosquitopopulations.GeneticRIDLtechnology(ReleaseofInsectscarryinga DominantLethal)isaproposedmodificationthatinvolvesreleasinginsectsthatarehomozygousforarepressibledominant lethal genetic construct rather than being sterilized by irradiation, and could potentially overcome some technical difficultieswiththeconventionalSITtechnology.Usingthearboviraldiseasedengueasanexample,wecombinevector population dynamics and epidemiological models to explore the effect of a program of RIDL releases on disease transmission.Weusethesetoderiveapreliminaryestimateofthepotentialcost-effectivenessofvectorcontrolbyapplying estimatesofthecostsofSIT.Wepredictthatthisgeneticcontrolstrategycouldeliminatedenguerapidlyfromahuman community,andatlowerexpense(approximatelyUS$2,30percaseaverted)thanthedirectandindirectcostsofdisease (meanUS$86–190percaseofdengue).Thetheoreticalframeworkhaswiderpotentialuse;byappropriatelyadaptingor replacing each component of the framework (entomological, epidemiological, vector control bio-economics and health economics),itcouldbeappliedtoothervector-bornediseasesorvectorcontrolstrategiesandextendedtoincludeother healthinterventions. Citation:AlpheyN,AlpheyL,BonsallMB(2011)AModelFrameworktoEstimateImpactandCostofGenetics-BasedSterileInsectMethodsforDengueVector Control.PLoSONE6(10):e25384.doi:10.1371/journal.pone.0025384 Editor:PedroLagerbladOliveira,Universidad