A Novel Ecdysone Receptor Mediates Steroid-Regulated Developmental Events during the Mid-Third Instar of Drosophila 英文参考文献.docVIP

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A Novel Ecdysone Receptor Mediates Steroid-Regulated Developmental Events during the Mid-Third Instar of Drosophila 英文参考文献.doc

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A Novel Ecdysone Receptor Mediates Steroid-Regulated Developmental Events during the Mid-Third Instar of Drosophila 英文参考文献

ANovelEcdysoneReceptorMediatesSteroid-Regulated DevelopmentalEventsduringtheMid-ThirdInstarof Drosophila BenjaminF.B.Costantino1,DanielK.Bricker1,KellyAlexandre1¤a,KateShen1,JohnR.Merriam2, ChristopheAntoniewski3,JennaL.Callender4,VincentC.Henrich4,AsafPresente1¤b,AndrewJ.Andres1* 1School of Life Sciences, University ofNevada Las Vegas, Las Vegas, Nevada, United States of America, 2Department of Molecular, Celland Developmental Biology, UniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesofAmerica,3DepartmentofDevelopmentalBiology,InstitutPasteur,Paris,France,4Centerfor Biotechnology,Genomics,andHealthResearch,UniversityofNorthCarolinaGreensboro,Greensboro,NorthCarolina,UnitedStatesofAmerica Abstract ThelarvalsalivaryglandofDrosophilamelanogastersynthesizesandsecretesglueglycoproteinsthatcementdeveloping animalstoasolidsurfaceduringmetamorphosis.Thesteroidhormone20-hydroxyecdysone(20E)isanessentialsignaling molecule that modulates most of the physiological functions of the larval gland. At the end of larval development, it is knownthat20E—signalingthroughanuclearreceptorheterodimerconsistingofEcRandUSP—inducestheearlyandlate puffing cascade of the polytene chromosomes and causes the exocytosis of stored glue granules into the lumen of the gland.Ithasalsobeenreportedthatanearlierpulseofhormoneinducesthetemporallyandspatiallyspecifictranscriptional activation of the glue genes; however, the receptor responsible for triggering this response has not been characterized. Hereweshowthatthecoordinatedexpressionofthegluegenesmidwaythroughthethirdinstarismediatedby20Eacting toinducegenesoftheBroad Complex(BRC)through areceptorthat isnotanEcR/USPheterodimer.Thisresult isnovel because it demonstrates for the first time that at least some 20E-mediated, mid-larval, developmental responses are controlledbyanuncharacterizedreceptorthatdoesnotcontainanRXR-likecomponent. Citation: Costantino BFB, Bricker DK, Alexandre K, Shen K, Merriam JR, et al. (2008) A Nov