A Novel Form of Memory for Auditory Fear Conditioning at a Low-Intensity Unconditioned Stimulus 英文参考文献.docVIP

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A Novel Form of Memory for Auditory Fear Conditioning at a Low-Intensity Unconditioned Stimulus 英文参考文献.doc

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A Novel Form of Memory for Auditory Fear Conditioning at a Low-Intensity Unconditioned Stimulus 英文参考文献

ANovelFormofMemoryforAuditoryFearConditioning ataLow-IntensityUnconditionedStimulus AyumiKishioka1,FumiakiFukushima1,TamaeIto1,HirotakaKataoka1,HisashiMori1¤a,ToshioIkeda2¤b , ShigeyoshiItohara2,KenjiSakimura3,MasayoshiMishina1* 1DepartmentofMolecularNeurobiologyandPharmacology,GraduateSchoolofMedicine,UniversityofTokyo,Tokyo,Japan,2LaboratoryofBehavioralGenetics,Brain ScienceInstitute,RIKEN,Saitama,Japan,3DepartmentofCellularNeurobiology,BrainResearchInstitute,NiigataUniversity,Niigata,Japan Abstract Fearisoneofthemostpotentemotionalexperiencesandisanadaptivecomponentofresponsetopotentiallythreatening stimuli.Ontheotherhand,toomuchorinappropriatefearaccountsformanycommonpsychiatricproblems.Cumulative evidencesuggeststhattheamygdalaplaysacentralroleintheacquisition,storageandexpressionoffearmemory.Here, wedevelopedaninduciblestriatalneuronablationsystemintransgenicmice.Theablationofstriatalneuronsintheadult brain hardlyaffectedtheauditoryfearlearning underthestandardconditioninagreement withprevious studies.When conditionedwithalow-intensityunconditionedstimulus,however,theformationoflong-termfearmemorybutnotshort- tem memory was impaired in striatal neuron-ablated mice. Consistently, the ablation of striatal neurons 24h after conditioningwiththelow-intensityunconditionedstimulus,whenthelong-termfearmemorywasformed,diminishedthe retention of the long-term memory. Our results reveal a novel form of the auditory fear memory depending on striatal neuronsatthelow-intensityunconditionedstimulus. Citation: Kishioka A, Fukushima F, Ito T, Kataoka H, Mori H, et al. (2009) A Novel Form of Memory for Auditory Fear Conditioning at a Low-Intensity UnconditionedStimulus.PLoSONE4(1):e4157.doi:10.1371/journal.pone.0004157 Editor:DavidS.Vicario,RutgersUniversity,UnitedStatesofAmerica ReceivedSeptember9,2008;AcceptedNovember23,2008;PublishedJanuary9,2009 Copyright: ? 2009 Kishioka et al. This is an open-access article distributed under the terms of the Creative Commons Attrib