A Wingless Flight 英文参考文献.docVIP

Journal Club A Wingless Flight Xiang Yu T he Wnt/Wingless (Wg) pathway is an evolutionarily conserved signaling pathway that plays important roles in normal development and cancer, from worms and ?ies to mice and humans. Two papers, identifying the ?rst components of this pathway, initiated the active research ?eld of Wnt/Wg signal transduction and profoundly in?uenced my al. 1994; Siegfried et al. 1994) in the fruit?y Drosophila melanogaster. Embryos lacking the segment polarity gene wingless (wg) are completely covered with small pointed ridges (denticles) on their undersurface (ventral cuti