A Wingless Flight 英文参考文献.docVIP

Journal Club A Wingless Flight Xiang Yu T he Wnt/Wingless (Wg) pathway is an evolutionarily conserved signaling pathway that plays important roles in normal development and cancer, from worms and ?ies to mice and humans. Two papers, identifying the ?rst components of this pathway, initiated the active research ?eld of Wnt/Wg signal transduction and profoundly in?uenced my al. 1994; Siegfried et al. 1994) in the fruit?y Drosophila melanogaster. Embryos lacking the segment polarity gene wingless (wg) are completely covered with small pointed ridges (denticles) on their undersurface (ventral cuticle), Copyright: ? 2003 Xiang Yu.This is an open-access ar- ticle distributed under the terms of the Creative Com- mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. scienti?c career. In 1994 two groups, led by Norbert Perrimon and Roel Nusse, identi?ed the ?rst components of the Wg signaling pathway (Noordermeer et Abbreviations: APC, adenomatous polyposis coli; arm, armadillo; dsh, dishevelled; GSK3, glycogen synthase kinase 3; LEF/TCF, lymphoid enhance factor/T cell factor; porc, porcupine; Ubx, Ultrabithorax; wg, wingless; WRS,Wingless response sequence; zw3, zeste-white 3 Xiang Yu is a postdoctoral research fellow in the laboratory of Robert C. Malenka in the Department of Psychiatry and Behavioral Sciences at Stanford Uni- versity Medical Center in Palo Alto, California, United States of America. E-mail: yuxiang@ Journal Club is a forum for postdoctoral scientists and graduate students to discuss an important paper in the context of their own scienti?c interests. DOI: 10.1371/journal/pbio.0000049 PLoS Biology | Volume 1 | Issue 3 | Page 324  in contrast to wild-type embryos, which have an alternating pattern of naked cuticle and denticle belts (Cadigan and Nusse 1997). Similar phenotypes were observed in a number of other mutations, including dishevelled (dsh), p