- 1、本文档共3页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
A Wingless Flight 英文参考文献
Journal Club
A Wingless Flight
Xiang Yu
T
he Wnt/Wingless (Wg) pathway
is an evolutionarily conserved
signaling pathway that plays
important roles in normal development
and cancer, from worms and ?ies
to mice and humans. Two papers,
identifying the ?rst components of this
pathway, initiated the active research
?eld of Wnt/Wg signal transduction
and profoundly in?uenced my
al. 1994; Siegfried et al. 1994) in the
fruit?y Drosophila melanogaster. Embryos
lacking the segment polarity gene
wingless (wg) are completely covered
with small pointed ridges (denticles)
on their undersurface (ventral cuticle),
Copyright: ? 2003 Xiang Yu.This is an open-access ar-
ticle distributed under the terms of the Creative Com-
mons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium,
provided the original work is properly cited.
scienti?c career.
In 1994 two groups, led by Norbert
Perrimon and Roel Nusse, identi?ed
the ?rst components of the Wg
signaling pathway (Noordermeer et
Abbreviations: APC, adenomatous polyposis coli; arm,
armadillo; dsh, dishevelled; GSK3, glycogen synthase
kinase 3; LEF/TCF, lymphoid enhance factor/T cell
factor; porc, porcupine; Ubx, Ultrabithorax; wg, wingless;
WRS,Wingless response sequence; zw3, zeste-white 3
Xiang Yu is a postdoctoral research fellow in the
laboratory of Robert C. Malenka in the Department of
Psychiatry and Behavioral Sciences at Stanford Uni-
versity Medical Center in Palo Alto, California, United
States of America. E-mail: yuxiang@
Journal Club is a forum for postdoctoral scientists
and graduate students to discuss an important paper
in the context of their own scienti?c interests.
DOI: 10.1371/journal/pbio.0000049
PLoS Biology |
Volume 1 | Issue 3 | Page 324
in contrast to wild-type embryos, which
have an alternating pattern of naked
cuticle and denticle belts (Cadigan
and Nusse 1997). Similar phenotypes
were observed in a number of other
mutations, including dishevelled (dsh),
p
您可能关注的文档
- A Small Community Model for the Transmission of Infectious Diseases Comparison of School Closure as an Intervention in Individual-Based Models of an Influenza Pandemic 英文参考文献.doc
- A Small Mammal Community in a Forest Fragment, Vegetation Corridor and Coffee Matrix System in the Brazilian Atlantic Forest 英文参考文献.doc
- A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity 英文参考文献.doc
- A Small Genomic Region Containing Several Loci Required for Gastrulation in Drosophila 英文参考文献.doc
- A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo 英文参考文献.doc
- A Smart Mutation Scheme Produces Hundreds of Functional Proteins 英文参考文献.doc
- A SNAP-Tagged Derivative of HIV-1—A Versatile Tool to Study Virus-Cell Interactions 英文参考文献.doc
- A Smell That Causes Seizure 英文参考文献.doc
- A Snapshot of Histone Modifications within Transposable Elements in Drosophila Wild Type Strains 英文参考文献.doc
- A Small Molecule SMAC Mimic LBW242 Potentiates TRAIL- and Anticancer Drug-Mediated Cell Death of Ovarian Cancer Cells 英文参考文献.doc
- 四川省德阳市罗江中学2025届高三考前热身化学试卷含解析.doc
- 山东省枣庄现代实验学校2025届高三下学期第五次调研考试化学试题含解析.doc
- 吉林省长春市十一高中等九校教育联盟2025届高三一诊考试生物试卷含解析.doc
- 2025届江苏省盐城市伍佑中学高考仿真模拟化学试卷含解析.doc
- 2025届广西贺州中学高考冲刺押题(最后一卷)生物试卷含解析.doc
- 安徽省池州市贵池区2025届高三第一次模拟考试生物试卷含解析.doc
- 宁夏银川一中2025届高三(最后冲刺)化学试卷含解析.doc
- 广东省广州市增城区四校联考2025届高考压轴卷化学试卷含解析.doc
- 2025届邯郸市第一中学高考生物必刷试卷含解析.doc
- 2025届安徽省安庆市石化第一中学高考仿真卷化学试卷含解析.doc
文档评论(0)