A Wnt-FrzRor-Dsh Pathway Regulates Neurite Outgrowth in Caenorhabditis elegans 英文参考文献.docVIP

下载本文档

3
0
约5.71万字
约 12页
2017-05-11 发布于上海
举报
版权申诉

A Wnt-FrzRor-Dsh Pathway Regulates Neurite Outgrowth in Caenorhabditis elegans 英文参考文献.doc

1、本文档共12页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

A Wnt-FrzRor-Dsh Pathway Regulates Neurite Outgrowth in Caenorhabditis elegans 英文参考文献

AWnt-Frz/Ror-DshPathwayRegulatesNeurite OutgrowthinCaenorhabditiselegans SongSong1,2.,BoZhang1,2.,HuiSun1,XiaLi1,YanhuiXiang1,2,ZhonghuaLiu1,XunHuang1* ,Mei Ding1* 1KeyLaboratoryofMolecularandDevelopmentalBiology,InstituteofGeneticsandDevelopmentalBiology,ChineseAcademyofSciences,Beijing,China,2Graduate School,ChineseAcademyofSciences,Beijing,China Abstract Oneofthechallengestounderstandtheorganizationofthenervoussystemhasbeentodeterminehowaxonguidance moleculesgovernaxonoutgrowth.Throughanunbiasedgeneticscreen,weidentifiedaconservedWntpathwaywhichis crucial for anterior-posterior (A/P) outgrowth of neurites from RME head motor neurons in Caenorhabditis elegans . The pathwayiscomposedoftheWntligandCWN-2,theFrizzledreceptorsCFZ-2andMIG-1,theco-receptorCAM-1/Ror,andthe downstreamcomponentDishevelled/DSH-1.Amongthese,CWN-2actsasalocalattractivecueforneuriteoutgrowth,and itsactivitycanbepartiallysubstitutedwithotherWnts,suggestingthatspatialdistributionplaysaroleinthefunctional specificityofWnts.Asaco-receptor,CAM-1functionscell-autonomouslyinneuronsand,togetherwithCFZ-2andMIG-1, transmits the Wnt signal to downstream effectors. Yeast two-hybrid screening identified DSH-1 as a binding partner for CAM-1,indicatingthatCAM-1couldfacilitateCWN-2/WntsignalingbyitsphysicalassociationwithDSH-1.Ourstudyreveals animportantroleofaWnt-Frz/Ror-DshpathwayinregulatingneuriteA/Poutgrowth. Citation:SongS,ZhangB,SunH,LiX,XiangY,etal.(2010)AWnt-Frz/Ror-DshPathwayRegulatesNeuriteOutgrowthinCaenorhabditiselegans.PLoSGenet6(8): e1001056.doi:10.1371/journal.pgen.1001056 Editor:SusanE.Mango,HarvardUniversity,UnitedStatesofAmerica ReceivedJanuary25,2010;AcceptedJuly8,2010;PublishedAugust12,2010 Copyright: ? 2010 Song et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ResearchreportedherewassupportedbytheNation