Activation of Wntβ-Catenin Signalling Affects Differentiation of Cells Arising from the Cerebellar Ventricular Zone 英文参考文献.docVIP

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Activation of Wntβ-Catenin Signalling Affects Differentiation of Cells Arising from the Cerebellar Ventricular Zone 英文参考文献.doc

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Activation of Wntβ-Catenin Signalling Affects Differentiation of Cells Arising from the Cerebellar Ventricular Zone 英文参考文献

ActivationofWnt/b-CateninSignallingAffects DifferentiationofCellsArisingfromtheCerebellar VentricularZone HaydenJ.Selvadurai¤,JohnO.Mason* CentreforIntegrativePhysiology,SchoolofBiomedicalSciences,UniversityofEdinburgh,Edinburgh,UnitedKingdom Abstract Developmentofthecerebellumproceedsundertheprecisespatio-temporalcontrolofseveralkeydevelopmentalsignalling pathways, including the Wnt/b-catenin pathway. We recently reported the activity of Wnt/b-catenin signalling in the perinatalcerebellarventricularzone(VZ),agerminalcentreinthedevelopingcerebellumthatgivesrisetoGABAergicand glialcells.InordertoinvestigatethenormalfunctionofWnt/b-cateninsignallingintheVZandthecelllineagesitgivesrise to, we used a combination of ex vivo cerebellar slice culture and in vivo geneticmanipulation to dysregulate its activity duringlateembryonicdevelopment.Activationofthepathwayatthecerebellarventricularzoneledtoareductioninthe numberofcellsexpressingthegliallineagemarkersSox9andGFAPandtheinterneuronmarkerPax2,buthadnoconsistent effect on either proliferation or apoptosis. Our findings suggest that activation of the Wnt/b-catenin pathway in the cerebellarventricularzonecausesashiftinthecelltypesproduced,mostlikelyduetodisruptionofnormaldifferentiation. Thus,weproposethatregulationofWnt/b-cateninsignallinglevelsarerequiredfornormaldevelopmentofcellsarising fromthecerebellarventricularzoneduringlateembryogenesis. Citation:SelvaduraiHJ,MasonJO(2012)ActivationofWnt/b-CateninSignallingAffectsDifferentiationofCellsArisingfromtheCerebellarVentricularZone.PLoS ONE7(8):e42572.doi:10.1371/journal.pone.0042572 Editor:BrandenNelson,SeattleChildren’sResearchInstitute,UnitedStatesofAmerica ReceivedMarch24,2012;AcceptedJuly9,2012;PublishedAugust3,2012 Copyright:?2012Selvadurai,Mason.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thisworkwa