Adaptable Functionality of Transcriptional Feedback in Bacterial Two-Component Systems 英文参考文献.docVIP

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Adaptable Functionality of Transcriptional Feedback in Bacterial Two-Component Systems 英文参考文献.doc

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Adaptable Functionality of Transcriptional Feedback in Bacterial Two-Component Systems 英文参考文献

AdaptableFunctionalityofTranscriptionalFeedbackin BacterialTwo-ComponentSystems J.ChristianJ.Ray,OlegA.Igoshin* DepartmentofBioengineering,RiceUniversity,Houston,Texas,UnitedStatesofAmerica Abstract Awidespreadmechanismofbacterialsignalingoccursthroughtwo-componentsystems,comprisedofasensorhistidine kinase(SHK)andatranscriptionalresponse regulator(RR).TheSHK activatesRRby phosphorylation.The mostcommon two-componentsystemstructureinvolvesexpressionfromasingleoperon,thetranscriptionofwhichisactivatedbyits ownphosphorylatedRR.Theroleofthisfeedbackispoorlyunderstood,butithasbeenassociatedwithanovershooting kineticresponseandwithfastrecoveryofpreviousinterruptedsignalingeventsindifferentsystems.Mathematicalmodels showthatovershootisonlyattainablewithnegativefeedbackthatalsoimprovesresponsetime.Ourmodelsalsopredict thatfastrecoveryofpreviousinterruptedsignalingdependsonhighaccumulationofSHKandRR,whichismorelikelyina positivefeedbackregime.WeuseMonteCarlosamplingoftheparameterspacetoexploretherangeofattainablemodel behaviors. The model predicts that the effective feedback sign can change from negative to positive depending on the signal level. Variations in two-component system architectures and parameters may therefore have evolved to optimize responsesindifferentbacteriallifestyles.Weproposeaconceptualmodelwherelowsignalconditionsresultinaresponsive systemwitheffectivelynegativefeedbackwhilehighsignalconditionswithpositivefeedbackfavorpersistenceofsystem output. Citation:RayJCJ,IgoshinOA(2010)AdaptableFunctionalityofTranscriptionalFeedbackinBacterialTwo-ComponentSystems.PLoSComputBiol6(2):e1000676. doi:10.1371/journal.pcbi.1000676 Editor:MarkGoulian,UniversityofPennsylvania ReceivedAugust17,2009;AcceptedJanuary12,2010;PublishedFebruary12,2010 Copyright: ? 2010 Ray, Igoshin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheorigina