Advanced Paternal Age Is Associated with Impaired Neurocognitive Outcomes during Infancy and Childhood 英文参考文献.docVIP
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Advanced Paternal Age Is Associated with Impaired Neurocognitive Outcomes during Infancy and Childhood 英文参考文献
o
PL SMEDICINE
AdvancedPaternalAgeIsAssociatedwith
ImpairedNeurocognitiveOutcomesduring
InfancyandChildhood
Sukanta Saha1[,Adrian G.Barnett2[,Claire Foldi3,Thomas H.Burne1,3,Darryl W. Eyles1,3,Stephen L.Buka4,
John J.McGrath1,3,5*
1QueenslandCentreforMentalHealthResearch,TheParkCentreforMentalHealth,Richlands,Australia,2InstituteofHealthandBiomedicalInnovationandSchoolof
PublicHealth,QueenslandUniversityofTechnology,KelvinGrove,Australia,3QueenslandBrainInstitute,TheUniversityofQueensland,St.Lucia,Australia,4Departmentof
CommunityHealth,BrownUniversity,Providence,RhodeIsland,UnitedStatesofAmerica,5DepartmentofPsychiatry,TheUniversityofQueensland,St.Lucia,Australia
Funding:Theauthorsreceivedno
specificfundingforthisarticle.
ABSTRACT
CompetingInterests:Theauthors
havedeclaredthatnocompeting
interestsexist.
Background
Advanced paternal age (APA) is associated with an increased risk of neurodevelopmental
disorderssuchasautismandschizophrenia,aswellaswithdyslexiaandreducedintelligence.
Theaimofthisstudywastoexaminetherelationshipbetweenpaternalageandperformance
onneurocognitivemeasuresduringinfancyandchildhood.
AcademicEditor:CarolBrayne,
UniversityofCambridge,United
Kingdom
Citation:SahaS,BarnettAG,FoldiC,
BurneTH,EylesDW,etal.(2009)
Advancedpaternalageisassociated
withimpairedneurocognitive
MethodsandFindings
outcomesduringinfancyand
childhood.PLoSMed6(3):e1000040.
doi:10.1371/journal.pmed.1000040
Asampleofsingletonchildren(n?33,437)wasdrawnfromtheUSCollaborativePerinatal
Project. The outcome measures were assessed at 8 mo, 4 y, and 7 y (Bayley scales, Stanford
Binet Intelligence Scale, Graham-Ernhart Block Sort Test, Wechsler Intelligence Scale for
Children, Wide Range Achievement Test). The main analyses examined the relationship
betweenneurocognitivemeasuresandpaternalormaternalagewhenadjustedforpotential
confounding factors. Advanced paternal age showed significant associations with poorer
scoresonalloftheneurocognitivemeasuresapartfromtheBayleyMotorscore.Thef
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