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Age Correction in Dementia – Matching to a Healthy Brain 英文参考文献
AgeCorrectioninDementia–MatchingtoaHealthy
Brain
JuergenDukart1,3*,MatthiasL.Schroeter1,2,3,KarstenMueller1,TheAlzheimer’sDiseaseNeuroimaging
Initiative
1MaxPlanckInstituteforHumanCognitiveandBrainSciences,Leipzig,Germany,2DayClinicofCognitiveNeurology,UniversityofLeipzig,Leipzig,Germany,3LIFE-
LeipzigResearchCenterforCivilizationDiseases,UniversityofLeipzig,Germany
Abstract
Inrecentresearch,manyunivariateandmultivariateapproacheshavebeenproposedtoimproveautomaticclassificationof
variousdementiasyndromesusingimagingdata.Someofthesemethodsdonotprovidethepossibilitytointegratepossible
confoundingvariableslikeageintothestatisticalevaluation.Asimilarproblemsometimesexistsinclinicalstudies,asitisnot
always possible to match different clinical groups to each other in all confounding variables, like for example, early-onset
(age,65years)andlate-onset(age$65)patientswithAlzheimer’sdisease(AD).Here,weproposeasimplemethodtocontrol
forpossibleeffectsofconfoundingvariablessuchasagepriortostatisticalevaluationofmagneticresonanceimaging(MRI)
datausingsupportvectormachineclassification(SVM)orvoxel-basedmorphometry(VBM).WecompareSVMresultsforthe
classificationof80ADpatientsand79healthycontrol subjects basedonMRIdatawithandwithoutprioragecorrection.
Additionally,wecompareVBMresultsforthecomparisonofthreedifferentgroupsofADpatientsdifferinginagewiththesame
groupofcontrolsubjectsobtainedwithoutincludingageascovariate,withageascovariateorwithprioragecorrectionusing
theproposedmethod.SVMclassificationusingtheproposedmethodresultedinhigherbetween-groupclassificationaccuracy
comparedtouncorrecteddata.Further,applyingtheproposedagecorrectionsubstantiallyimprovedunivariatedetectionof
disease-relatedgreymatteratrophyusingVBMinADpatientsdifferinginagefromcontrolsubjects.Theresultssuggestthatthe
approachproposedinthisworkisgenerallysuitedtocontrolforconfoundingvariablessuchasageinSVMorVBManalyses.
Accordingly,theapproachmightimproveandextendtheapplicationofthesemethodsinclinicalneuroscie
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