Aging Impairs Recipient T Cell Intrinsic and Extrinsic Factors in Response to Transplantation 英文参考文献.docVIP

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Aging Impairs Recipient T Cell Intrinsic and Extrinsic Factors in Response to Transplantation 英文参考文献.doc

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Aging Impairs Recipient T Cell Intrinsic and Extrinsic Factors in Response to Transplantation 英文参考文献

AgingImpairsRecipientTCellIntrinsicandExtrinsic FactorsinResponsetoTransplantation HuaShen.,BethanyM.Tesar.,WeiDu,DanielR.Goldstein* DepartmentofInternalMedicine,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,UnitedStatesofAmerica Abstract Background:Asincreasingnumbersofolderpeoplearelistedforsolidorgantransplantation,thereisanurgentneedto betterunderstandhowagingmodifiesalloimmuneresponses.Here,weinvestigatedwhetheragingimpairstheabilityof donordendriticcellsorrecipientimmunitytoprimealloimmuneresponsestoorgantransplantation. PrincipalFindings:Usingmurineexperimentalmodels,wefoundthatagingimpairedthehostenvironmenttoexpandand activateantigenspecificCD8 Tcells.Additionally,agingimpairedtheabilityofpolyclonalTcellstoinduceacuteallograft rejection.However,thealloimmuneprimingcapabilityofdonordendriticcellswaspreservedwithaging. + Conclusion:Agingimpairsrecipientresponses,bothTcellintrinsicandextrinsic,inresponsetoorgantransplantation. Citation:ShenH,TesarBM,DuW,GoldsteinDR(2009)AgingImpairsRecipientTCellIntrinsicandExtrinsicFactorsinResponsetoTransplantation.PLoSONE4(1): e4097.doi:10.1371/journal.pone.0004097 Editor:DeryaUnutmaz,NewYorkUniversitySchoolofMedicine,UnitedStatesofAmerica ReceivedAugust28,2008;AcceptedNovember26,2008;PublishedJanuary1,2009 Copyright: ? 2009 Shen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyNIHgrantsAI064660andAG028082toDRG.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decision topublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:daniel.goldstein@ .Theseauthorscontributedequallytothiswork. Introduction presentstudywastodeterminewhetheragingimpairsalloimmune primingfunctionofdonorDCs,recipientDCsorTcellintrinsic alloimmune responses. We provide