Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition 英文参考文献.docVIP

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Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition 英文参考文献.doc

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Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition 英文参考文献

AktDeficiencyAttenuatesMuscleSizeandFunctionbut NottheResponsetoActRIIBInhibition MarcusD.Goncalves1,3,EmidioE.Pistilli2,AnthonyBalduzzi1,MorrisJ.Birnbaum1,3,JenniferLachey4, TejvirS.Khurana2,RexfordS.Ahima1,3* 1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 2Department of Physiology and PennsylvaniaMuscleInstitute,UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica,3InstituteforDiabetes,Obesityand Metabolism,UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica,4AcceleronPharma,Cambridge,Massachusetts,United StatesofAmerica Abstract Background:Aktisacriticalmediatorofdevelopmentalskeletalmusclegrowth.TreatmentwithasolubleActRIIBfusion protein(ActRIIB-mFc)increasesskeletalmusclemassandstrengthbyinhibitingmyostatinandrelatedpeptides.Recentin vitro studies have suggested that Akt signaling is necessary for the ability of ActRIIB inhibition to induce muscle hypertrophy.Thus,wehypothesizedthatmicedeficientineitherAkt1orAkt2wouldnotrespondtoinvivoinhibitionof ActRIIBwithActRIIB-mFctreatment. MethodologyandPrincipalFindings:Weanalyzedbodycompositionandmuscleparametersinwild-typeC57BL/6Jand Akt1 and Akt2 knockout mice, and compared the responses to blockade of ActRIIB signaling via ActRIIB-mFc treatment. MicelackingAkt1orAkt2hadreducedmusclemass,gripstrengthandcontractileforce.However,deficiencyofAkt1orAkt2 didnotpreventtheabilityofActRIIB-mFctreatmenttoinducemusclehypertrophy,orincreasegripstrengthandcontractile force.Akt1andAkt2deficientmicerespondedsimilarlyaswildtypemicetoActRIIB-mFctreatmentbyincreasingfibersize. Conclusions and Significance: Akt1 and Akt2 are important for the regulation of skeletal muscle mass and function. However,theseAktisoformsarenotessentialfortheabilityofActRIIBinhibitiontoregulatemusclesize,fibertype,strength orcontractileforce. Citation:GoncalvesMD,PistilliEE,BalduzziA,BirnbaumMJ,LacheyJ,etal