Altered Brain Activity during Reward Anticipation in Pathological Gambling and Obsessive-Compulsive Disorder 英文参考文献.docVIP

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Altered Brain Activity during Reward Anticipation in Pathological Gambling and Obsessive-Compulsive Disorder 英文参考文献.doc

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Altered Brain Activity during Reward Anticipation in Pathological Gambling and Obsessive-Compulsive Disorder 英文参考文献

AlteredBrainActivityduringRewardAnticipationin PathologicalGamblingandObsessive-Compulsive Disorder Jung-SeokChoi1,2,Young-ChulShin3,WiHoonJung4,JoonHwanJang1,Do-HyungKang1 ,Chi- HoonChoi5,Sam-WookChoi6,Jun-YoungLee1,2,JaeYeonHwang2,7,JunSooKwon1,4,7 * 1DepartmentofPsychiatry,SeoulNationalUniversityCollegeofMedicine,Seoul,Korea,2DepartmentofPsychiatry,SMG-SNUBoramaeMedicalCenter,Seoul,Korea, 3DepartmentofPsychiatry,KangbukSamsungHospital,SungkyunkwanUniversitySchoolofMedicine,Seoul,Korea,4InstituteofHumanBehavioralMedicine,SNU-MRC, Seoul,Korea,5DepartmentofRadiology,NationalMedicalCenter,Seoul,Korea,6DepartmentofAddictionRehabilitationandSocialWelfare,EuljiUniversity,Seongnam, Korea,7BrainCognitiveScience-WCUprogram,CollegeofNaturalScience,SNU,Seoul,Korea Abstract Background: Pathological gambling (PG) and obsessive-compulsive disorder (OCD) are conceptualized as a behavioral addiction, with a dependency on repetitive gambling behavior and rewarding effects following compulsive behavior, respectively.However,noneuroimagingstudiestodatehaveexaminedrewardcircuitryduringtheanticipationphaseof rewardinPGcomparedwithinOCDwhileconsideringrepetitivegamblingandcompulsionasaddictivebehaviors. Methods/PrincipalFindings:Toelucidatetheneuralactivitiesspecifictotheanticipationphaseofreward,weperformed event-related functionalmagnetic resonanceimaging (fMRI)in youngadults with PGandcompared themwiththosein patients with OCD and healthy controls. Fifteen male patients with PG, 13 patients with OCD, and 15 healthy controls, group-matched for age, gender, and IQ, participated in a monetary incentive delay task during fMRI scanning. Neural activation in the ventromedial caudate nucleus during anticipation of both gain and loss decreased in patients with PG comparedwiththatinpatientswithOCDandhealthycontrols.Additionally,reducedactivationintheanteriorinsuladuring anticipationoflosswasobservedinpatients withPGcomparedwiththatinpatientswithOCDwhichwasintermediate betweenthatinOCDa