Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi An Animal Model for Coincident AIDS and Relapsing Malaria 英文参考文献.docVIP

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Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi An Animal Model for Coincident AIDS and Relapsing Malaria 英文参考文献.doc

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Altered Immune Responses in Rhesus Macaques Co-Infected with SIV and Plasmodium cynomolgi An Animal Model for Coincident AIDS and Relapsing Malaria 英文参考文献

AlteredImmuneResponsesinRhesusMacaquesCo- InfectedwithSIVandPlasmodiumcynomolgi:AnAnimal ModelforCoincidentAIDSandRelapsingMalaria JeffreyW.Koehler1*,MichaelBolton1,AmandaRollins2,KirstenSnook2,EileendeHaro3 ,Elizabeth Henson4,LindaRogers4,LouisN.Martin3,DonaldJ.Krogstad5,MarkA.James5,JanetRice6 ,Billie Davison4,RonaldS.Veazey4,RameshPrabhu1,AngelaM.Amedee7,RobertF.Garry1,FrankB.Cogswell2 1DepartmentofMicrobiologyandImmunology,TulaneUniversitySchoolofMedicine,NewOrleans,Louisiana,UnitedStatesofAmerica,2DepartmentofBacteriology and Parasitology, Tulane National Primate Research Center, Covington, Louisiana, United States of America, 3Department of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America, 4Department of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana,UnitedStatesofAmerica,5DepartmentofTropicalMedicine,TulaneUniversitySchoolofPublicHealthandTropicalMedicine,NewOrleans,Louisiana,United StatesofAmerica,6DepartmentofEpidemiology,TulaneUniversitySchoolofPublicHealthandTropicalMedicine,NewOrleans,Louisiana,UnitedStatesofAmerica, 7DepartmentofMicrobiology,Immunology,andParasitology,LouisianaStateUniversityHealthSciencesCenter,NewOrleans,Louisiana,UnitedStatesofAmerica Abstract Background: Dual epidemics of the malaria parasite Plasmodium and HIV-1 in sub-Saharan Africa and Asia present a significant risk for co-infection in these overlapping endemic regions. Recent studies of HIV/Plasmodium falciparum co- infectionhavereportedsignificantinteractionsofthesepathogens,includingmorerapidCD4+Tcellloss,increasedviral load,increasedimmunosuppression,andincreasedepisodesofclinicalmalaria.Here,wedescribeanovelrhesusmacaque modelforco-infectionthatsupportsandexpandsuponfindingsinhumanco-infectionstudiesandcanbeusedtoidentify interactionsbetweenthesetwopathogens. Methodology/Principal Findings: Five rhesus macaques were infected with P. cynomolgi and, following three parasite relapses,