Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment 英文参考文献.docVIP

下载本文档

1
0
约7.69万字
约 15页
2017-05-11 发布于上海
举报
版权申诉

Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment 英文参考文献.doc

1、本文档共15页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment 英文参考文献

AlteredRegulationofAktSignalingwithMurineCerebral Malaria,EffectsonLong-TermNeuro-CognitiveFunction, RestorationwithLithiumTreatment MinxianDai1,2.,BrandiFreeman2.,HenryJ.Shikani2.,FernandoPereiraBruno2,J.EliasCollado3, RolandoMacias4,SandraE.Reznik1,PeterDavies2,5,6,DavidConoverSpray5,7 ,Herbert BernardTanowitz2,7,LouisMartinWeiss2,7,MahaliaSabrinaDesruisseaux2,7 * 1Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John’s University, Queens, New York, United States of America, 2DepartmentofPathology,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,3PontificiaUniversidadCatolicaMadreyMaestra,Santiago, DominicanRepublic,4MeharryMedicalCollege,Nashville,Tennessee,UnitedStatesofAmerica,5TheDominickP.PurpuraDepartmentofNeuroscience,AlbertEinstein CollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,6Litwin-ZuckerCenterfortheStudyofAlzheimer’sDiseaseandMemoryDisorders,FeinsteinInstitutefor Medical Research, Manhasset,New York, United States ofAmerica, 7Department ofMedicine,Albert Einstein CollegeofMedicine,Bronx, New York, United States of America Abstract Neurologicalandcognitiveimpairmentpersistinmorethan20%ofcerebralmalaria(CM)patientslongaftersuccessfulanti- parasitictreatment.Werecentlyreportedthatlongtermmemoryandmotorcoordinationdeficitsarealsopresentinour experimental cerebral malaria model (ECM). We also documented, in a murine model, a lack of obvious pathology or inflammation after parasite elimination, suggesting that the long-term negative neurological outcomes result from potentially reversible biochemical and physiological changes in brains of ECM mice, subsequent to acute ischemic and inflammatoryprocesses.Here,wedemonstrateforthefirsttimethatacuteECMresultsinsignificantlyreducedactivationof protein kinase B (PKB or Akt) leading to decreased Akt phosphorylation and inhibition of the glycogen kinase synthase (GSK3b)inthebrainsofmiceinfectedwithPlasmodiumbergheiANKA(PbA)comparedtouninfectedco