Altered Topological Properties of Functional Network Connectivity in Schizophrenia during Resting State A Small-World Brain Network Study 英文参考文献.docVIP

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Altered Topological Properties of Functional Network Connectivity in Schizophrenia during Resting State A Small-World Brain Network Study 英文参考文献.doc

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Altered Topological Properties of Functional Network Connectivity in Schizophrenia during Resting State A Small-World Brain Network Study 英文参考文献

AlteredTopologicalPropertiesofFunctionalNetwork ConnectivityinSchizophreniaduringRestingState:A Small-WorldBrainNetworkStudy QingbaoYu1*,JingSui1,SrinivasRachakonda1,HaoHe1,2,WilliamGruner1,2,GodfreyPearlson3,4,KentA. Kiehl1,5,VinceD.Calhoun1,2,3,4 * 1TheMindResearchNetwork,Albuquerque,NewMexico,UnitedStatesofAmerica,2DepartmentofElectricalandComputerEngineering,UniversityofNewMexico, Albuquerque, New Mexico, United States of America, 3Olin Neuropsychiatry Research Center, Hartford, Connecticut, United States of America, 4Department of Psychiatry,YaleUniversity,NewHaven,Connecticut,UnitedStatesofAmerica,5DepartmentofPsychology,UniversityofNewMexico,Albuquerque,NewMexico,United StatesofAmerica Abstract Aberrant topological properties of small-world human brain networks in patients with schizophrenia (SZ) have been documented in previous neuroimaging studies. Aberrant functional network connectivity (FNC, temporal relationships amongindependentcomponenttimecourses)hasalsobeenfoundinSZbyapreviousrestingstatefunctionalmagnetic resonanceimaging(fMRI)study.However,nostudyhasyetdeterminediftopologicalpropertiesofFNCarealsoalteredin SZ.Inthisstudy,small-worldnetworkmetricsofFNCduringtherestingstatewereexaminedinbothhealthycontrols(HCs) and SZ subjects. FMRI data were obtained from 19 HCs and 19 SZ. Brain images were decomposed into independent components (ICs) by group independent component analysis (ICA). FNC maps were constructed via a partial correlation analysis of ICA time courses. A set of undirected graphs were built by thresholding the FNC maps and the small-world networkmetricsofthesemapswereevaluated.OurresultsdemonstratedsignificantlyalteredtopologicalpropertiesofFNC inSZrelativetocontrols.Inaddition,topologicalmeasuresofmanyICsinvolvingfrontal,parietal,occipitalandcerebellar areaswerealteredinSZrelativetocontrols.Specifically,topologicalmeasuresofwholenetworkandspecificcomponentsin SZwerecorrelatedwithscoresonthenegativesymptomscaleofthePositiveandNegativeSympto