Alternative Splicing of sept9a and sept9b in Zebrafish Produces Multiple mRNA Transcripts Expressed Throughout Development 英文参考文献.docVIP

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Alternative Splicing of sept9a and sept9b in Zebrafish Produces Multiple mRNA Transcripts Expressed Throughout Development 英文参考文献.doc

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Alternative Splicing of sept9a and sept9b in Zebrafish Produces Multiple mRNA Transcripts Expressed Throughout Development 英文参考文献

AlternativeSplicingofsept9aandsept9binZebrafish ProducesMultiplemRNATranscriptsExpressed ThroughoutDevelopment MeganL.Landsverk1,3.,DouglasC.Weiser2,4.,MarkC.Hannibal1,DavidKimelman2* 1DepartmentofPediatrics,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,2DepartmentofBiochemistry,UniversityofWashington,Seattle, Washington, United States of America, 3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, 4DepartmentofBiologicalSciences,UniversityofthePacific,Stockton,California,UnitedStatesofAmerica Abstract Background: Septins are involved in a number of cellular processes including cytokinesis and organization of the cytoskeleton.Alterationsinhumanseptin-9(SEPT9)levelshavebeenlinkedtomultiplecancers,whereasmutationsinSEPT9 causetheepisodicneuropathy,hereditaryneuralgicamyotrophy(HNA).Despiteitsimportantfunctioninhumanhealth,the invivoroleofSEPT9isunknown. Methodology/PrincipalFindings:HereweutilizezebrafishtostudytheroleofSEPT9inearlydevelopment.Weshowthat zebrafish possess two genes, sept9a and sept9b that, like humans, express multiple transcripts. Knockdown or overexpressionofsept9atranscriptsresultsinspecificdevelopmentalalterationsincludingcirculationdefectsandaberrant epidermaldevelopment. Conclusions/Significance: Our work demonstrates that sept9 plays an important role in zebrafish development, and establisheszebrafishasavaluablemodelorganismforthestudyofSEPT9. Citation:LandsverkML,WeiserDC,HannibalMC,KimelmanD(2010)AlternativeSplicingofsept9aandsept9binZebrafishProducesMultiplemRNATranscripts ExpressedThroughoutDevelopment.PLoSONE5(5):e10712.doi:10.1371/journal.pone.0010712 Editor:BruceRiley,TexasAMUniversity,UnitedStatesofAmerica ReceivedApril1,2010;AcceptedApril28,2010;PublishedMay19,2010 Copyright: ? 2010 Landsverk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andrepro