An Alternative and Effective HIV Vaccination Approach Based on Inhibition of Antigen Presentation Attenuators in Dendritic Cells 英文参考文献.docVIP

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An Alternative and Effective HIV Vaccination Approach Based on Inhibition of Antigen Presentation Attenuators in Dendritic Cells 英文参考文献.doc

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An Alternative and Effective HIV Vaccination Approach Based on Inhibition of Antigen Presentation Attenuators in Dendritic Cells 英文参考文献

o PL SMEDICINE AnAlternativeandEffectiveHIVVaccination ApproachBasedonInhibitionofAntigen PresentationAttenuatorsinDendriticCells Xiao-Tong Song1,2,Kevin Evel-Kabler1,3,Lisa Rollins1,3,Melissa Aldrich1,3,Feng Gao4,Xue F.Huang1,5,Si-Yi Chen1,2,3* 1CenterforCellandGeneTherapy,BaylorCollegeofMedicine,Houston,Texas,UnitedStatesofAmerica,2DepartmentofMolecularandHumanGenetics,BaylorCollegeof Medicine,Houston,Texas,UnitedStatesofAmerica,3DepartmentofImmunology,BaylorCollegeofMedicine,Houston,Texas,UnitedStatesofAmerica,4DukeHuman VaccineInstitute,DukeUniversityMedicalCenter,Durham,NorthCarolina,UnitedStatesofAmerica,5DepartmentofPediatrics,BaylorCollegeofMedicine,Houston,Texas, UnitedStatesofAmerica CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. ABSTRACT Background AuthorContributions:XTS,KEK, andSYCdesignedthestudyand analyzedthedata.XTS,KEK,LR,MA, FG,andXFHcarriedout CurrenteffortstodevelopHIVvaccinesthatseektostimulateimmuneresponseshavebeen disappointing, underscoring the inability of natural immune responses to control HIV-1 infection. Here we tested an alternative strategy to induce anti-HIV immune responses by inhibitingahost’snaturalimmuneinhibitor. experiments.SYCwrotethepaper. AcademicEditor:CliffordLane, NationalInstitutesofHealth,United StatesofAmerica MethodsandFindings Citation:SongXT,Evel-KablerK, RollinsL,AldrichM,GaoF,etal. (2006)Analternativeandeffective HIVvaccinationapproachbasedon inhibitionofantigenpresentation attenuatorsindendriticcells.PLoS Med3(1):e11. WeusedsmallinterferingRNA(siRNA)toinhibitsuppressorofcytokinesignaling(SOCS)1,a keynegativeregulatoroftheJAK/STATpathway,andinvestigatedtheeffectofthissilencingon theabilityofdendriticcells(DCs)toinduceanti-HIV-1immunity.WefoundthatSOCS1-silenced DCs broadly induced enhanced HIV-1 envelope (Env)-specific CD8t cytotoxic T lymphocytes and CD4tT helpercells, aswell as antibody responses, in mice. Importantly, SOCS1-silenced DCs were more resistant to HIV Env-mediated su