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An Exploratory Study on CLU, CR1 and PICALM and Parkinson Disease 英文参考文献
AnExploratoryStudyonCLU,CR1andPICALMand
ParkinsonDisease
JianjunGao1,XuemeiHuang2,YikYungPark3,AlbertHollenbeck4,HongleiChen1*
1EpidemiologyBranch ofthe NationalInstitute ofEnvironmental Health Sciences, ResearchTriangle Park, North Carolina, United States of America, 2Department of
Neurology,PennsylvaniaStateUniversity-MiltonS.HersheyMedicalCenter,Hershey,Pennsylvania,UnitedStatesofAmerica,3NutritionalEpidemiologyBranch,National
CancerInstitute,Rockville,Maryland,UnitedStatesofAmerica,4AARP,Washington,D.C.,UnitedStatesofAmerica
Abstract
Background:RecentGWASandsubsequentconfirmationstudiesreportedseveralsingle-nucleotidepolymorphisms(SNPs)
attheCLU,CR1andPICALMlociinassociationwithlate-onsetAlzheimer’sdisease(AD).Parkinsondisease(PD)sharesseveral
clinicalandpathologiccharacteristicswithAD;wethereforeexploredwhethertheseSNPswerealsoassociatedwithPDrisk.
Methodology/PrincipalFindings:791non-HispanicWhitescasesand1,580matchedcontrolswereincludedinthestudy.
Oddsratios(OR)and95%confidenceintervals(CI)wereobtainedfromlogisticregressionmodels.rttheCLU
locus was associated with PD risk under the recessive model (comparing TT versus CC+CT: OR=0.71, 95% CI: 0.55-0.92,
p=0.008)afteradjustingforyearofbirth,gender,smoking,andcaffeineintake.FurtheradjustmentforfamilyhistoryofPD
and ApoE e4 status did not change the result. In addition, we did not find evidence for effect modification by ApoE or
knownPDriskfactors.Theassociation,however,appearedtobestrongerforPDwithdementia(OR=0.49,95%CI:0.27-
0.91)thanforPDwithoutdementia(OR=0.81,95%CI:0.61-1.06).ThetwootherSNPs,rs6656401fromCR1,andrs3851179
fromPICALMregionwerenotassociatedwithPD(p.0.05).
Conclusion: Our exploratory analysis suggests an association of CLU with PD. This exploratory finding and the role of
dementiainexplainingthisfindingneedsfurtherinvestigation.
Citation:GaoJ,HuangX,ParkY,HollenbeckA,ChenH(2011)AnExploratoryStudyonCLU,CR1andPICALMandParkinsonDisease.PLoSONE6(8):e24211.
doi:10.1371/journal.pone.00242
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