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An Automated Paradigm for Drosophila Visual Psychophysics 英文参考文献
AnAutomatedParadigmforDrosophilaVisual
Psychophysics
OliverEvans,AngeliqueC.Paulk,BrunovanSwinderen*
QueenslandBrainInstitute,TheUniversityofQueensland,Brisbane,Queensland,Australia
Abstract
Background: Mutations that cause learning and memory defects in Drosophila melanogaster have been found to also
compromise visual responsiveness and attention. A better understanding of attention-like defects in such Drosophila
mutantsthereforerequiresamoredetailedcharacterizationofvisualresponsivenessacrossarangeofvisualparameters.
Methodology/Principal Findings: We designed an automated behavioral paradigm for efficiently dissecting visual
responsiveness in Drosophila. Populations of flies walk through multiplexed serial choice mazes while being exposed to
movingvisualsdisplayedoncomputermonitors,andinfra-redflycountersattheendofeachmazeautomaticallyscorethe
responsiveness of a strain. To test our new design, we performed a detailed comparison between wild-type flies and a
learningandmemorymutant,dunce1.Wefirstconfirmedthatthelearningmutantdunce1displaysincreasedresponsiveness
to a black/green moving grating compared to wild type in this new design. We then extended this result to explore
responsestoawiderangeofpsychophysicalparametersformovinggratings(e.g.,luminosity,contrast,spatialfrequency,
velocity) as well as to a different stimulus, moving dots. Finally, we combined these visuals (gratings versus dots) in
competitiontoinvestigatehowdunce1andwild-typefliesrespondtomorecomplexandconflictingmotioneffects.
Conclusions/Significance: We found that dunce1 responds more strongly than wild type to high contrast and highly
structured motion. This effect was found for simple gratings, dots, and combinations of both stimuli presented in
competition.
Citation: Evans O, Paulk AC, van Swinderen B (2011) An Automated Paradigm for Drosophila Visual Psychophysics. PLoS ONE 6(6): e21619. doi:10.1371/
journal.pone.0021619
Editor:AlexanderBorst,Max-PlanckInstituteofNeurobiology,Germany
R
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