An In Vitro and In Vivo Analysis of the Correlation between Susceptibility-Weighted Imaging Phase Values and R2 in Cirrhotic Livers 英文参考文献.docVIP

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An In Vitro and In Vivo Analysis of the Correlation between Susceptibility-Weighted Imaging Phase Values and R2 in Cirrhotic Livers 英文参考文献.doc

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An In Vitro and In Vivo Analysis of the Correlation between Susceptibility-Weighted Imaging Phase Values and R2 in Cirrhotic Livers 英文参考文献

AnInVitroandInVivoAnalysisoftheCorrelation betweenSusceptibility-WeightedImagingPhaseValues andR2*inCirrhoticLivers RanTao1,4.,JiuquanZhang1.,YongmingDai2,ZhonglanYou3,YiFan3,JinguoCui4*,JianWang1* 1DepartmentofRadiology,SouthwestHospital,ThirdMilitaryMedicalUniversity,Chongqing,China,2MRCollaborationNEAsia,SiemensHealthcare,Shanghai,China, 3DepartmentofInfectiousDiseases,SouthwestHospital,ThirdMilitaryMedicalUniversity,Chongqing,China,4DepartmentofRadiology,BethuneInternationalPeace HospitalofPeople’sLibertyArmy,Shijiazhuang,HebeiProvince,China Abstract Objective: To establish a baseline of susceptibility-weighted imaging (SWI) phase value as a means of detecting iron abnormalitiesincirrhoticliverandtoanalyzeitsrelationshipwithR2*. MaterialsandMethods:SixteenMnCl2phantoms,thirty-sevenhealthyindividualsand87cirrhoticpatientswereperformed SWI and multi-echo T2*-weighted imaging, and the signal processing in NMR (SPIN) software was used to measure the radianonSWIphaseimagesandtheR2*onT2*maps.Themeanminustwotimesstandarddeviation(SD)ofSiemensPhase Unit(SPU)inhealthyindividualswasdesignatedasathresholdtoseparatetheregionsofinterest(ROIs)intohigh-andlow- ironareasinhealthyparticipantsandcirrhoticpatients.TheSWIphasevaluesofhigh-ironareaswerecalculated.TheR2* valueswasmeasuredinthesameROIinbothhealthyparticipantsandpatients. Results:SWIphasevaluescorrelatedlinearlywithR2*valuesincasesofMnCl2concentrationslowerthan2.3mMinvitro (r=20.996,P,0.001).ThemeanvalueandSDof37healthyparticipantswere2003and15(SPU),respectively.Athreshold of 1973 SPU (20.115 radians) was determined. The SWI phase value and R2* values had a negative correlation in the cirrhotic patients (r=20.742, P,0.001). However, no similar relationship was found in the healthy individuals (r=0.096, P=0.576). Both SWI phase values and R2* values were found to have significant correlations with serum ferritin concentrationsin42patientswithbloodsamples(r=20.512,P=0.001andr=0.641,P,0.001,respectively). Conclusion: SW