Angiopoietin-1 Treatment Reduces Inflammation but Does Not Prevent Ventilator-Induced Lung Injury 英文参考文献.docVIP

下载本文档

3
0
约4.28万字
约 9页
2017-05-11 发布于上海
举报
版权申诉

Angiopoietin-1 Treatment Reduces Inflammation but Does Not Prevent Ventilator-Induced Lung Injury 英文参考文献.doc

1、本文档共9页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Angiopoietin-1 Treatment Reduces Inflammation but Does Not Prevent Ventilator-Induced Lung Injury 英文参考文献

Angiopoietin-1TreatmentReducesInflammationbut DoesNotPreventVentilator-InducedLungInjury MariaA.Hegeman1,2.,MarijeP.Hennus2.,MatijsvanMeurs3,4,PieterM.Cobelens1,5 ,Annemieke Kavelaars1,NicolaasJ.Jansen2,MarcusJ.Schultz6,AdrianusJ.vanVught2,GrietjeMolema4,CobiJ. Heijnen1* 1Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands, 2Department of Pediatric IntensiveCare,UniversityMedicalCenterUtrecht,Utrecht,TheNetherlands,3DepartmentofCriticalCare,UniversityMedicalCenterGroningen,UniversityofGroningen, Groningen,TheNetherlands,4MedicalBiologySection,DepartmentofPathologyandMedicalBiology,UniversityMedicalCenterGroningen,UniversityofGroningen, Groningen, The Netherlands, 5Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands, 6Laboratory of Experimental IntensiveCareandAnesthesiology,DepartmentofIntensiveCareMedicine,AcademicMedicalCenter,Amsterdam,TheNetherlands Abstract Background:Lossofintegrityoftheepithelialandendothelialbarriersisthoughttobeaprominentfeatureofventilator- induced lung injury (VILI). Based on its function in vascular integrity, we hypothesize that the angiopoietin (Ang)-Tie2 system plays a role in the development of VILI. The present study was designed to examine the effects of mechanical ventilationontheAng-Tie2systeminlungtissue.Moreover,weevaluatedwhethertreatmentwithAng-1,aTie2receptor agonist,protectsagainstinflammation,vascularleakageandimpairedgasexchangeinducedbymechanicalventilation. Methods: Mice were anesthetized, tracheotomized and mechanically ventilated for 5hours with either an inspiratory pressureof10cmH O(‘low’tidalvolume,7.5ml/kg;LV )or18cmH O(‘high’tidalvolume,15ml/kg;HV ).Atinitiation 2 T 2 T ofHVT-ventilation,recombinanthumanAng-1wasintravenouslyadministered(1or4 mgperanimal).Non-ventilatedmice servedascontrols. Results:HVT-ventilationinfluencedtheAng-Tie2systeminlungsofhealthymicesinceAng-1,Ang-2an