Angiostatic Factors in the Pulmonary Endarterectomy Material from Chronic Thromboembolic Pulmonary Hypertension Patients Cause Endothelial Dysfunction 英文参考文献.docVIP

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Angiostatic Factors in the Pulmonary Endarterectomy Material from Chronic Thromboembolic Pulmonary Hypertension Patients Cause Endothelial Dysfunction 英文参考文献.doc

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Angiostatic Factors in the Pulmonary Endarterectomy Material from Chronic Thromboembolic Pulmonary Hypertension Patients Cause Endothelial Dysfunction 英文参考文献

AngiostaticFactorsinthePulmonaryEndarterectomy MaterialfromChronicThromboembolicPulmonary HypertensionPatientsCauseEndothelialDysfunction DianaZabini1,ChandranNagaraj1,7,ElviraStacher2,IreneM.Lang3,PatrickNierlich4,WalterKlepetko4, AkosHeinemann5,HorstOlschewski6,Zolta′nBa′lint1,7*,AndreaOlschewski1,7 1Experimental Anesthesiology, Department of Anesthesia and Intensive Care Medicine, Medical University of Graz, Graz, Austria, 2Institute of Pathology, Medical University of Graz, Graz, Austria, 3Department ofInternalMedicineII, Division ofCardiology, Medical University ofVienna, Vienna, Austria, 4Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria, 5Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria, 6Division of Pulmonology,DepartmentofInternalMedicine,MedicalUniversityofGraz,Graz,Austria,7LudwigBoltzmannInstituteforLungVascularResearch,Graz,Austria Abstract Chronicthromboembolicpulmonaryhypertension(CTEPH)isararediseasewithpersistentthromboticocclusionorstenosis of the large pulmonary arteries resulting in pulmonary hypertension. Surgical removal of the neointimal layer of these vesselstogetherwiththenon-resolvedthrombusconsistingoforganizedcollagen-richfibroticareaswithpartlyrecanalized regions is the treatment of choice (pulmonary endarterectomy, PEA). The present study investigates endothelial cells isolatedfromsuchmaterialaswellasfactorspresentinthesurgicalPEAmaterial,whichmaycontributetoimpairmentof recanalizationandthrombusnon-resolution.Weobservedmuscularizedvesselsandnon-muscularizedvesselsinthePEA material. The isolated endothelial cells from the PEA material showed significantly different calcium homeostasis as comparedtopulmonaryarteryendothelialcells(hPAECs)fromnormalcontrols.Inthesupernatant(ELISA)aswellasonthe tissue level (histochemical staining) of the PEA material, platelet factor 4 (PF4), collagen type I and interferon-gamma- inducible10kDprotein(IP-10)weredetected.CXCR3,therec