Angiotensin-(1–7) and the G Protein-Coupled Receptor Mas Are Key Players in Renal Inflammation 英文参考文献.docVIP

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Angiotensin-(1–7) and the G Protein-Coupled Receptor Mas Are Key Players in Renal Inflammation 英文参考文献.doc

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Angiotensin-(1–7) and the G Protein-Coupled Receptor Mas Are Key Players in Renal Inflammation 英文参考文献

Angiotensin-(1–7)andtheGProtein-CoupledReceptor MasAreKeyPlayersinRenalInflammation VanesaEsteban1,SilviaHeringer-Walther2,3,AnjaSterner-Kock4,RondeBruin5,SandravandenEngel5, YongWang3,6,SergioMezzano7,JesusEgido1,Heinz-PeterSchultheiss3,MartaRuiz-Ortega1. ,Thomas Walther3,6. * 1CellularBiologyinRenalDiseasesLaboratory,Fundacio′nJimenezDiaz,UniversidadAuto′nomaMadrid,Madrid,Spain,2DepartmentofObstetrics,UniversityofLeipzig, Leipzig,Germany,3DepartmentofCardiology,Charite′,CampusBenjaminFranklin(CBF),Berlin,Germany,4InstituteforVeterinaryPathology,FreieUniversita¨t, Berlin, Germany,5DepartmentofSurgery,ErasmusMedicalCenter,Rotterdam,TheNetherlands,6CentreforBiomedicalResearch,HullYorkMedicalSchool,UniversityofHull, Hull,UnitedKingdom,7DivisionofNephrology,SchoolofMedicine,UniversidadAustral,Valdivia,Chile Abstract Angiotensin(Ang)IImediatespathophysiologialchangesinthekidney.Ang-(1–7)byinteractingwiththeGprotein-coupled receptorMasmayalsohaveimportantbiologicalactivities. In this study, renal deficiency for Mas diminished renal damage in models of renal insufficiency as unilateral ureteral obstructionandischemia/reperfusioninjurywhiletheinfusionofAng-(1–7)towild-typemicepronouncedthepathological outcomebyaggravatingtheinflammatoryresponse.MasdeficiencyinhibitedNF-kBactivationandthustheelevationof inflammation-stimulating cytokines, while Ang-(1–7) infusion had proinflammatory properties in experimental models of renalfailureaswellasunderbasalconditions.TheAng-(1–7)-mediatedNF-kBactivationwasMasdependentbutdidnot involveAngIIreceptors.Therefore,theblockadeoftheNF-kB-activatingpropertiesofthereceptorMascouldbeanew strategyinthetherapyoffailingkidney. Citation:EstebanV,Heringer-WaltherS,Sterner-KockA,deBruinR,vandenEngelS,etal.(2009)Angiotensin-(1–7)andtheGProtein-CoupledReceptorMasAre KeyPlayersinRenalInflammation.PLoSONE4(4):e5406.doi:10.1371/journal.pone.0005406 Editor:CarmineZoccali,L’IstitutodiBiomedicinaedImmunologiaMolecolare,ConsiglioNazionaledelleRice