Antenatal Screening for Down Syndrome Using Serum Placental Growth Factor with the Combined, Quadruple, Serum Integrated and Integrated Tests 英文参考文献.docVIP

下载本文档

11
0
约3.17万字
约 9页
2017-05-11 发布于上海
举报
版权申诉

Antenatal Screening for Down Syndrome Using Serum Placental Growth Factor with the Combined, Quadruple, Serum Integrated and Integrated Tests 英文参考文献.doc

1、本文档共9页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Antenatal Screening for Down Syndrome Using Serum Placental Growth Factor with the Combined, Quadruple, Serum Integrated and Integrated Tests 英文参考文献

AntenatalScreeningforDownSyndromeUsingSerum PlacentalGrowthFactorwiththeCombined,Quadruple, SerumIntegratedandIntegratedTests NicholasJ.Wald*,JonathanP.Bestwick,LynneM.George,WayneJ.Huttly WolfsonInstituteofPreventiveMedicine,BartsandtheLondonSchoolofMedicineandDentistry,QueenMaryUniversityofLondon,London,UnitedKingdom Abstract Objective: To estimate the value of first or second trimester placental growth factor (PlGF) as an additional antenatal screeningmarkerforDownsyndrome. Design:Nestedcase-controlstudy. Setting:Antenatalscreeningservice. PopulationorSample:532Downsyndromepregnanciesand1,155matchedunaffectedpregnancies. Methods:Storedmaternalserumsamples(240uC)wereassayedforPlGF.MonteCarlosimulationwasusedtoestimatethe screeningperformanceofPlGFwiththeCombined,Quadruple,serumIntegratedandIntegratedtests. Main Outcome Measures: Median PlGF levels in affected and unaffected pregnancies and screening performance (detectionrates[DR]forspecifiedfalse-positiverates[FPR]andviceversa). Results:FirsttrimestermedianPlGFwas15%,28%and39%lowerinDownsyndromethanunaffectedpregnanciesat11,12 and13completedweeks’gestationrespectively(allp,0.001).SecondtrimestermedianPlGFwas31%lowerat14weeks (p,0.001),andthedifferencedecreased(6%lowerat17weeks).Ata90%DRwithfirsttrimestermarkersmeasuredat13 weeks,addingPlGFdecreasedtheFPRfrom11.1to5.1%usingtheCombinedtest,9.3%to4.5%usingtheserumIntegrated test,and3.4%to1.5%usingtheIntegratedtest(or1.5to1.4%withfirsttrimestermarkersmeasuredat11weeks).Adding PlGFtotheQuadrupletest(measuredat15weeks)decreasedtheFPRfrom10.0%to9.6%ata90%DR. Conclusions:FirsttrimesterPlGFmeasurementsimprovetheperformanceofantenatalscreeningforDownsyndromeusing theCombined,serumIntegratedandIntegratedtests.SecondtrimesterPlGFmeasurementsareoflimitedvalue. Citation:WaldNJ,BestwickJP,GeorgeLM,HuttlyWJ(2012)AntenatalScreeningforDownSyndromeUsingSerumPlacentalGrowthFactorwiththeCombined, Quadruple,SerumIntegratedandIntegratedTests.PLoSONE7(10):e46955.doi:10.1371/journal.po