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Aortic Wave Dynamics and Its Influence on Left Ventricular Workload 英文参考文献
AorticWaveDynamicsandItsInfluenceonLeft
VentricularWorkload
NiemaM.Pahlevan1,MortezaGharib2*
1Option ofBioengineering, Division ofEngineering AppliedSciences, California Institute ofTechnology, Pasadena, California, United States of America, 2Graduate
AerospaceLaboratories,DivisionofEngineeringAppliedSciences,CaliforniaInstituteofTechnology,Pasadena,California,UnitedStatesofAmerica
Abstract
Thepumpingmechanismoftheheartispulsatile,sotheheartgeneratespulsatileflowthatentersintothecompliantaorta
intheformofpressureandflowwaves.Wehypothesizedthatthereexistsaspecificheartrateatwhichtheexternalleft
ventricular(LV)powerisminimized.Totestthishypothesis,weusedacomputationalmodeltoexploretheeffectsofheart
rate(HR)andaorticrigidityonleftventricular(LV)powerrequirement.Whilebothmeanandpulsatilepartsofthepressure
play an important role in LV power requirement elevation, at higher rigidities the effect of pulsatility becomes more
dominant.Foranygivenaorticrigidity,thereexistsanoptimumHRthatminimizestheLVpowerrequirementatagiven
cardiacoutput.TheoptimumHRshiftstohighervaluesastheaortabecomesmorerigid.Toconclude,thereisanoptimum
conditionforaorticwavesthatminimizestheLVpulsatileloadandconsequentlythetotalLVworkload.
Citation: Pahlevan NM, Gharib M (2011) Aortic Wave Dynamics and Its Influence on Left Ventricular Workload. PLoS ONE 6(8): e23106. doi:10.1371/
journal.pone.0023106
Editor:AravinthanSamuel,HarvardUniversity,UnitedStatesofAmerica
ReceivedMarch30,2011;AcceptedJuly6,2011;PublishedAugust11,2011
Copyright:?2011Pahlevan,Gharib.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:Thisresearchefforthasbeenfundedbyunrestricted(researchtopicorpublicationapproval)giftfundsfromFletcherJonesfoundation,Medtronic
Corp,andCharykFamilyfoundation.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpr
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