Arterial Embolization Hyperthermia Using As2O3 Nanoparticles in VX2 Carcinoma–Induced Liver Tumors 英文参考文献.docVIP

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Arterial Embolization Hyperthermia Using As2O3 Nanoparticles in VX2 Carcinoma–Induced Liver Tumors 英文参考文献.doc

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Arterial Embolization Hyperthermia Using As2O3 Nanoparticles in VX2 Carcinoma–Induced Liver Tumors 英文参考文献

ArterialEmbolizationHyperthermiaUsingAs2O3 NanoparticlesinVX2Carcinoma–InducedLiverTumors HuiYu1,Guang-YuZhu1,Rui-ZhiXu2,Huan-ZhangNiu1,QinLu1,Guo-ZhaoLi1,Zi-YuWang3, Dong-ShengZhang3,NingGu2,Gao-JunTeng1* 1JiangsuKeyLaboratoryofMolecularImagingandFunctionalImaging,DepartmentofRadiology,Zhong-DaHospital,MedicalSchoolofSoutheastUniversity,Nanjing, China, 2Jiangsu Laboratory for Biomaterials and Devices, State Key Laboratory of BioElectronics, School of Biological Science and Medical Engineering, Southeast University,Nanjing,China,3DepartmentofPathologyandPathophysiology,MedicalSchoolofSoutheastUniversity,Nanjing,China Abstract Background:Combinationtherapyforarterialembolizationhyperthermia(AEH)witharsenictrioxide(As2O3 )nanoparticles (ATONs)isanoveltreatmentforsolidmalignancies.Thisstudywasperformedtoevaluatethefeasibilityandtherapeutic effectofAEHwithAs2O3nanoparticlesinarabbitlivercancermodel.Theprotocolwasapprovedbyourinstitutionalanimal usecommittee. Methodology/Principal Findings: In total, 60 VX2 liver-tumor-bearing rabbits were randomly assigned to five groups (n=12/group)andreceivedAEHwithATONs(Group1),hepaticarterialembolizationwithATONs(Group2),lipiodol(Group 3),orsaline(Group4),onday14aftertumorimplantation.TwelverabbitsthatreceivedAEHwithATONswerepreparedfor temperature measurements, and were defined as Group 5. Computed tomography was used to measure the tumors’ longestdimension,andevaluationwasperformedaccordingtotheResponseEvaluationCriteriainSolidTumors.Hepatic toxicity, tumornecrosis rate,vascular endothelialgrowthfactor level,and microvesseldensity weredetermined.Survival rates were measured using the Kaplan-Meier method. The therapeutic temperature (42.5uC) was obtained in Group 5. Hepatotoxicityreactionsoccurredbutweretransientinallgroups.Tumorgrowthwasdelayedandsurvivalwasprolonged inGroup1(treatedwithAEHandATONs).Plasmaandtumorvascularendothelialgrowthfactorandmicrovesseldensity weresignificantlyinhibitedinGroup1,whiletumornecrosisrateswerem