Arachidonic Acid Drives Postnatal Neurogenesis and Elicits a Beneficial Effect on Prepulse Inhibition, a Biological Trait of Psychiatric Illnesses 英文参考文献.docVIP

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Arachidonic Acid Drives Postnatal Neurogenesis and Elicits a Beneficial Effect on Prepulse Inhibition, a Biological Trait of Psychiatric Illnesses 英文参考文献.doc

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Arachidonic Acid Drives Postnatal Neurogenesis and Elicits a Beneficial Effect on Prepulse Inhibition, a Biological Trait of Psychiatric Illnesses 英文参考文献

ArachidonicAcidDrivesPostnatalNeurogenesisand ElicitsaBeneficialEffectonPrepulseInhibition,a BiologicalTraitofPsychiatricIllnesses MotokoMaekawa1,2.,NorikoTakashima3.,MihoMatsumata1,4,ShiroIkegami5,MasanoriKontani6, YoshinobuHara1,4,HiroshiKawashima6,YujiOwada7,YoshinobuKiso6,TakeoYoshikawa2 ,Kaoru Inokuchi3,8,NorikoOsumi1,4 * 1DepartmentofDevelopmentalNeurobiology,TohokuUniversityGraduateSchoolofMedicine,Sendai,Japan,2LaboratoryforMolecularPsychiatry,RIKENBrainScience Institute, Saitama, Japan, 3Mitsubishi Kagaku Institute of Life Sciences (MITILS), Tokyo, Japan, 4CREST, Japan Science and Technology Corporation (JST), Kawaguchi, Japan,5SaitamaInstituteofTechnology,Saitama,Japan,6InstituteforHealthCareScience,SuntoryCo.Ltd.,Osaka,Japan,7DepartmentofOrganAnatomy,Yamaguchi UniversityGraduateSchoolofMedicine,Yamaguchi,Japan,8GraduateSchoolofEnvironmentandInformationSciences,YokohamaNationalUniversity,Yokohama,Japan Abstract Prepulseinhibition(PPI)isacompellingendophenotype(biologicalmarkers)formentaldisordersincludingschizophrenia. In a previous study, we identified Fabp7, a fatty acid binding protein 7 as one of the genescontrolling PPI in mice and showed that this gene was associated with schizophrenia. We also demonstrated that disrupting Fabp7 dampened hippocampalneurogenesis.Inthisstudy,weexaminedalinkbetweenneurogenesisandPPIusingdifferentanimalmodels and exploring the possibility of postnatal manipulation of neurogenesis affecting PPI, since gene-deficient mice show biological disturbances from prenatal stages. In parallel, we tested the potential for dietary polyunsaturated fatty acids (PUFAs),arachidonicacid(ARA)and/ordocosahexaenoicacid(DHA),topromoteneurogenesisandimprovePPI.PUFAsare ligandsforFabpmembersandareabundantlyexpressedinneuralstem/progenitorcellsinthehippocampus.Ourresults are:(1)anindependentmodelanimal,Pax6(+/2)rats,exhibitedPPIdeficitsalongwithimpairedpostnatalneurogenesis;(2) methylazoxymethanolacetate(ananti-proliferativedrug)eliciteddecre