Association between FGFR1OP2wit3.0 Polymorphisms and Residual Ridge Resorption of Mandible in Korean Population 英文参考文献.docVIP

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Association between FGFR1OP2wit3.0 Polymorphisms and Residual Ridge Resorption of Mandible in Korean Population 英文参考文献.doc

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Association between FGFR1OP2wit3.0 Polymorphisms and Residual Ridge Resorption of Mandible in Korean Population 英文参考文献

AssociationbetweenFGFR1OP2/wit3.0Polymorphisms andResidualRidgeResorptionofMandibleinKorean Population JeeHwanKim1,MinYoungOh1,JanghyunPaek2,JaehoonLee1* 1DepartmentofProsthodontics,CollegeofDentistry,YonseiUniversity,Seoul,Korea,2DepartmentofProsthodontics,KyungHeeUniversityDentalHospital,Seoul,Korea Abstract Background:ApreviousstudyonthegeneticassociationbetweensinglenucleotidepolymorphismsinFGFR1OP2/wit3.0 andthelongtermatrophyofedentulousmandiblehypothesizedthattheexcessivejawboneatrophyafterdentalextraction maybeassociatedwithabnormaloralmucosacontractioninducedbytheFGFR1OP2/wit3.0gene.Itwasreportedthatthe minor allele of rs840869 or rs859024 in FGFR1OP2/wit3.0 was associated with the excessive atrophy of edentulous mandible. The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population. Methodology/PrincipalFindings:134subjects(70.4669.02years)withpartiallyorcompletelyedentulousmandiblewere recruited.ThemandibularboneheightwasmeasuredfollowingtheprotocoloftheAmericanCollegeofProsthodontists (ACP).From24subjects,sevenvariantsinFGFR1OP2werediscoveredandfourofthemwerenovel.SelectedSNPsthatare notinhighLDatr2thresholdof0.8weregenotypedfortheremainingpopulation.Therewasnofrequencyoftheminor alleleofSNPrs859024inKoreanpopulation.SNPrs840869wasnotassociatedwithresidualridgeresorption(p=0.479).The boneheightofthesubjectwiththess518063493minorallele(8.52mm)wasshorterthanthatofthosesubjectswithmajor alleles(18.9665.33mm,p=0.053). Conclusions/Significance: The patient with minor allele of ss518063493 may be associated with excessive atrophy of edentulousmandiblewhereasthepatientswiththatofrs840869arenotassociatedinKoreanpopulation.Theresultfrom this study may assist in developing a novel genetic diagnostic test and be useful in identifying Koreans susceptible to developingexcessivejawboneatrophyafterdentale