Association of Eleven Common, Low-Penetrance Colorectal Cancer Susceptibility Genetic Variants at Six Risk Loci with Clinical Outcome 英文参考文献.docVIP
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Association of Eleven Common, Low-Penetrance Colorectal Cancer Susceptibility Genetic Variants at Six Risk Loci with Clinical Outcome 英文参考文献
AssociationofElevenCommon,Low-Penetrance
ColorectalCancerSusceptibilityGeneticVariantsatSix
RiskLociwithClinicalOutcome
JanelleM.Hoskins1.,Pei-ShiOng1,*.¤a,TemitopeO.Keku2,JosephA.Galanko2,3,ChristopherF.Martin2,
ClintA.Coleman1¤b,MichelleWolfe2,RobertS.Sandler2,HowardL.McLeod1,4,5
1DivisionofPharmacotherapyandExperimentalTherapeutics,InstituteforPharmacogenomicsandIndividualizedTherapy,EshelmanSchoolofPharmacy,Universityof
NorthCarolinaatChapelHill,ChapelHill,NorthCarolina,UnitedStatesofAmerica,2DivisionofGastroenterologyandHepatology,UniversityofNorthCarolinaatChapel
Hill,ChapelHill,NorthCarolina,UnitedStatesofAmerica,3CenterforGastrointestinalBiologyandDisease,DivisionofGastroenterologyandHepatology,Universityof
NorthCarolinaatChapelHill,ChapelHill,NorthCarolina,UnitedStatesofAmerica,4DivisionofHematologyandOncology,UniversityofNorthCarolinaatChapelHill,
Chapel Hill, North Carolina, United States of America, 5The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North
Carolina,UnitedStatesofAmerica
Abstract
Background: Low-penetrance genetic variants have been increasingly recognized to influence the risk of tumor
development.Riskvariantsforcolorectalcancer(CRC)havebeenmappedtochromosomepositions8q23.3,8q24,9p24.1,
10p14,11q23,14q22.2,15q13,16q22.1,18q21,19q13.1and20p12.3.Inparticular,the8q24singlenucleotidepolymorphism
(SNP),rs6983267,hasreproduciblybeenassociatedwiththeriskofdevelopingCRC.AstheCRCriskSNPsmayalsoinfluence
diseaseoutcome,thusinthisstudy,weevaluatedwhethertheyinfluencepatientsurvival.
Methodology/PrincipalFindings:DNAsamplesfrom583CRCpatientsenrolledintheprospective,NorthCarolinaCancer
CareOutcomesResearchandSurveillanceConsortiumStudy(NCCanCORS)weregenotypedfor11CRCsusceptibilitySNPs
at6CRCriskloci.RelationshipsbetweengenotypesandpatientsurvivalwereexaminedusingCoxregressionanalysis.In
multivariate analysis, patients homozygous for the CRC risk allele of rs7013278 or rs7014346 (both at 8q24) were
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