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Association of Genetic Loci with Blood Lipids in the Chinese Population 英文参考文献
AssociationofGeneticLociwithBloodLipidsinthe
ChinesePopulation
ZhouZhang1,2.,LimingTao1.,ZhuoChen1,DaizhanZhou1,MengyuanKan1,DiZhang1,CanLi3 ,Lin
He2,3*,YunLiu2*
1Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences,
Shanghai, People’s Republic of China, 2Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China, 3Bio-X Center, Key Laboratory of
DevelopmentalGeneticsandNeuropsychiatricDiseases(MinistryofEducation),ShanghaiJiaoTongUniversity,Shanghai,People’sRepublicofChina
Abstract
Background:Recentgenome-wideassociation(GWA)studieshaveidentifiedanumberofnovelgeneticdeterminantsof
blood lipid concentrations in Europeans. However, it is still unclear whether these loci identified in the Caucasian GWA
studiesalsoexertthesameeffectonlipidconcentrationsintheChinesepopulation.
MethodsandResults:WeconductedareplicationstudyassessingassociationsbetweenSNPsat15lociandbloodlipidand
lipoproteinconcentrationsintwoChinesecohorts,comprising2533and2105individualsrespectively.SNPsinAPO(A1/C3/
A4/A5),TIMD4-HAVCR1,DOCK7,TRIB1,ABCA1,andTOMM40-APOEshowedstrongassociationswithatleastonelipidstrait,
andrs174546inFADS1/2/3showedmodestassociationwithtriglycerideintheChinesepopulation.
Conclusions:Wesuccessfullyreplicated7lociassociatedplasmalipidconcentrationsintheChinesepopulation.Ourstudy
confirmed the implication of APO(A1/C3/A4/A5), TOMM40-APOE, ABCA1, DOCK7, TIMD4-HAVCR1, TRIB1 and FADS1/2 in
plasmalipidandlipoproteinconcentrationsinChinesepopulation.
Citation:ZhangZ,TaoL,ChenZ,ZhouD,KanM,etal.(2011)AssociationofGeneticLociwithBloodLipidsintheChinesePopulation.PLoSONE6(11):e27305.
doi:10.1371/journal.pone.0027305
Editor:NikolasNikolaidis,CaliforniaStateUniversityFullerton,UnitedStatesofAmerica
ReceivedApril7,2011;AcceptedOctober13,2011;PublishedNovember3,2011
Copyright: ? 2011 Zhang et al. This is an open-access article distributed under the t
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