Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women 英文参考文献.docVIP
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Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women 英文参考文献
AssociationofGeneticVariantsofMelatoninReceptor1B
withGestationalPlasmaGlucoseLevelandRiskof
GlucoseIntoleranceinPregnantChineseWomen
ShunyaoLiao1*.,YunqiangLiu2.,YuandeTan3,LuGan1,JieMei4,WenzhongSong5,ShuChi5,
XianjueDong6,XiaojuanChen7,ShaopingDeng1,8*
1DiabetesCenter,SichuanAcademyofMedicalScienceandSichuanProvincialPeople’sHospital,Chengdu,China, 2Department ofMedicalGeneticsandDivisionof
Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China, 3College of Life Science, Hunan Normal University,
Changsha, Hunan, China, 4Department of Obstetrics and Gynecology, Sichuan Academy of Medical Science, Sichuan Provincial People’s Hospital, Chengdu, China,
5ClinicalIsotopicLaboratory,SichuanAcademyofMedicalScience,SichuanProvincialPeople’sHospital,Chengdu,China,6DepartmentofEndocrinology,Chongqing
Medical University, Chongqing, China, 7Department of Surgery, Northwest University Hospital, Chicago, Illinois, United States of America, 8Human Islet Laboratory,
MassachusettsGeneralHospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica
Abstract
Background: This study aimed to explore the association of MTNR1B genetic variants with gestational plasma glucose
homeostasisinpregnantChinesewomen.
Methods:Atotalof1,985pregnantHanChinesewomenwererecruitedandevaluatedforgestationalglucosetolerance
statuswithatwo-stepapproach.ThefourMTNR1Bvariantsrrs1387153,rs1447352,andrs2166706whichhad
been reported to associate with glucose levels in general non-pregnant populations, were genotyped in these women.
Usinganadditivemodeladjustedforageandbodymassindex(BMI),associationofthesevariantswithgestationalfasting
and postprandial plasma glucose (FPG and PPG) levels were analyzed by multiple linear regression; relative risk of
developinggestationalglucoseintolerancewascalculatedbylogisticregression.Hardy-WeinbergEquilibriumwastestedby
Chi-squareandlinkagedisequilibrium(LD)betweenthesevariantswasestimatedby
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