Association of Glomerular Filtration Rate with High-Sensitivity Cardiac Troponin T in a Community-Based Population Study in Beijing 英文参考文献.docVIP
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Association of Glomerular Filtration Rate with High-Sensitivity Cardiac Troponin T in a Community-Based Population Study in Beijing 英文参考文献
AssociationofGlomerularFiltrationRatewithHigh-
SensitivityCardiacTroponinTinaCommunity-Based
PopulationStudyinBeijing
FanWang,PingYe*,LeimingLuo,RuyiXu,YongyiBai,HongmeiWu
DepartmentofGeriatricCardiology,ChinesePLAGeneralHospital,Beijing,China
Abstract
Background: Reduced renal function is an independent risk factor for cardiovascular disease mortality, and persistently
elevatedcardiactroponinT(cTnT)isfrequentlyobservedinpatientswithend-stagerenaldisease.Inthegeneralpopulation
therelationshipbetweenrenalfunctionandcTnTlevelsmaynotbeclearbecauseofthelowsensitivityoftheassay.Inthis
study,weinvestigatedthelevelofcTnTusingahighlysensitiveassay(hs-cTnT)andevaluatedtheassociationofestimated
glomerularfiltrationrate(eGFR)withdetectablehs-cTnTlevelsinacommunity-basedpopulation.
Methods: The serum hs-cTnT levels were measured in 1365 community dwelling population aged $45 years in Beijing,
China.eGFRwasdeterminedbytheChinesemodifyingmodificationofdietinrenaldisease(C-MDRD)equation.
Results:Withthehighlysensitiveassay,cTnTlevelsweredetectable($3pg/mL)in744subjects(54.5%).Theresultshowed
that eGFR was associated with Log hs-cTnT (r=20.14, P,0.001). After adjustment for the high predicted Framingham
CoronaryHeartDisease(CHD)risk(10-yearrisk.20%)andotherprognosticindicators,moderatetoseverereducedeGFR
was independently associated with detectable hs-cTnT, whereas normal to mildly reduced eGFR was not independently
associatedwithdetectablehs-cTnT.Inaddition,afteradjustmentforotherriskfactors,thehighpredictedFraminghamCHD
riskwasassociatedwithdetectablehs-cTnTinthesubjectswithdifferentquartilelevelsofeGFR.
Conclusion:Thelevelsofhs-cTnTaredetectableinacommunity-basedChinesepopulationandloweGFRisassociatedwith
detectablehs-cTnT.Moreover,eGFRandhighpredictedFraminghamCHDriskareassociatedwithdetectablehs-cTnTin
subjectswithmoderate-to-severereducedrenalfunction.
Citation:WangF,YeP,LuoL,XuR,BaiY,etal.(2012)AssociationofGlomerularFiltrationRatewithHigh-SensitivityCardiacTroponinTinaCom
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