Association of the Myostatin Gene with Obesity, Abdominal Obesity and Low Lean Body Mass and in Non-Diabetic Asian Indians in North India 英文参考文献.docVIP

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Association of the Myostatin Gene with Obesity, Abdominal Obesity and Low Lean Body Mass and in Non-Diabetic Asian Indians in North India 英文参考文献.doc

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Association of the Myostatin Gene with Obesity, Abdominal Obesity and Low Lean Body Mass and in Non-Diabetic Asian Indians in North India 英文参考文献

AssociationoftheMyostatinGenewithObesity, AbdominalObesityandLowLeanBodyMassandinNon- DiabeticAsianIndiansinNorthIndia SuryaPrakashBhatt1,2,3,PriyankaNigam4,AnoopMisra4,5*,RandeepGuleria2,KalpanaLuthra3, S.K.Jain6,M.A.QadarPasha7 1DepartmentofMedicine,AllIndiaInstituteofMedicalSciences,NewDelhi,India,2DepartmentofPulmonaryMedicineandSleepDisorders,AllIndiaInstituteofMedical Sciences,NewDelhi,India,3DepartmentofBiochemistry,AllIndiaInstituteofMedicalSciences,NewDelhi,India,4DiabeticFoundation(India)andNationalDiabetes ObesityandCholesterolFoundation(N-DOC),NewDelhi,India,5FortisC-DOCCenterofExcellenceforDiabetes,MetabolicDiseases,andEndocrinology,ChiragEnclave, NewDelhi,India,6DepartmentofBiotechnology,JamiaHamdard,NewDelhi,India,7InstituteofGenomicsandIntegrativeBiology,Delhi,India Abstract Background: To determine the association of the A55T and K153R polymorphisms of the Myostatin gene with obesity, abdominalobesityandleanbodymass(LBM)inAsianIndiansinnorthIndia. MaterialsandMethods:Atotalof335subjects(238menand97women)wereassessedforanthropometry,%bodyfat (BF),LBMandbiochemicalparameters.AssociationsofMyostatingenepolymorphismswereevaluatedwithanthropometric, body composition and biochemical parameters. In A55T polymorphism, BMI (p=0.04), suprailiac skinfold (p=0.05), total skinfold(p=0.008),%BF(p=0.002)andtotalfatmass(p=0.003)werehighestand%LBM(p=0.03)andtotalLBM(Kg)were lowest (p=0.04) in subjects with Thr/Thr genotype as compared to other genotypes. Association analysis of K153R polymorphism showed that subjects with R/R genotype had significantly higher BMI (p=0.05), waist circumference (p=0.04),%BF(p=0.04)andtotalfatmass(p=0.03),andlower%LBM(p=0.02)andtotalLBM[(Kg),(p=0.04)]ascompared toothergenotypes.Usingamultivariatelogistic regression modelafter adjustingforage andsex,subjects withThr/Thr genotypeofA55Tshowedhighriskforhigh%BF(OR,3.92,95%Cl:2.61–12.41),truncalsubcutaneousadiposity(OR,2.9, 95%Cl:1.57–6.60)]andlowLBM(OR,0.64,95%CI:0.33–0.89)whereasR/R