Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal Medulla 英文参考文献.docVIP

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Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal Medulla 英文参考文献.doc

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Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal Medulla 英文参考文献

AsthmaPregnancyAltersPostnatalDevelopmentof ChromaffinCellsintheRatAdrenalMedulla Xiu-MingWu.,Cheng-PingHu.,Xiao-ZhaoLi,Ye-QiangZou,Jun-TaoZou,Yuan-YuanLi,Jun-TaoFeng* DepartmentofRespiratoryMedicine,XiangyaHospital,CentralSouthUniversity,Changsha,Hunan,China Abstract Background:Adrenalneuroendocrineplaysanimportantroleinasthma.Theactivityofthesympathoadrenalsystemcould bealteredbyearlylifeevents.Theeffectsofmaternalasthmaduringpregnancyontheadrenalmedullaofoffspringremain unknown. Methodology/PrincipalFindings:Thisstudyaimstoexploretheinfluenceofmaternalasthmaduringpregnancyonthe developmentandfunctionofadrenalmedullainoffspringfrompostnatalday3(P3)topostnatalday60(P60).Asthmatic pregnant rats (AP), nerve growth factor (NGF)-treated pregnant rats (NP) and NGF antibody-treated pregnant rats (ANP) weresensitizedandchallengedwithovalbumin(OVA);NPandANPweretreatedwithNGFandNGFantibodyrespectively. Offspringratsfromthematernalgroupweredividedintofourgroups:offspringfromcontrolpregnantrats(OCP),offspring from AP (OAP), offspring from NP (ONP), and offspring from ANP (OANP). The expressions of phenylethanolamine N- methyltransferase(PNMT)proteininadrenalmedullawereanalyzed.Theconcentrationsofepinephrine(EPI),corticosterone andNGFinserumweremeasured.Adrenalmedullachromaffincells(AMCC)werepronetodifferentiateintosympathetic nervecellsinOAPandONP.BothEPIandPNMTweredecreasedinOAPfromP3toP14,andthenreachednormallevel gradually from P30 to P60, which were lower from birth to adulthood in ONP. Corticosterone concentration increased significantlyinOAPandONP. Conclusion/Significance:AsthmapregnancymaypromoteAMCCtodifferentiateintosympatheticneuronsinoffspringrats andinhibitthesynthesisofEPI,resultingindysfunctionofbronchialrelaxation. Citation: Wu X-M, Hu C-P, Li X-Z, Zou Y-Q, Zou J-T, et al. (2011) Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal Medulla.PLoSONE6(5):e20337.doi:10.1371/journal.pone.0020337 Editor:RoryEdwardMorty,UniversityofGi