Body Iron Stores and Heme-Iron Intake in Relation to Risk of Type 2 Diabetes A Systematic Review and Meta-Analysis 英文参考文献.docVIP

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Body Iron Stores and Heme-Iron Intake in Relation to Risk of Type 2 Diabetes A Systematic Review and Meta-Analysis 英文参考文献.doc

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Body Iron Stores and Heme-Iron Intake in Relation to Risk of Type 2 Diabetes A Systematic Review and Meta-Analysis 英文参考文献

BodyIronStoresandHeme-IronIntakeinRelationto RiskofType2Diabetes:ASystematicReviewandMeta- Analysis ZhuoxianZhao1,SheyuLi1,GuanjianLiu2,FangfangYan1,XueleiMa3,ZeyuHuang4,HaomingTian1* 1Department of Endocrinology and Metabolism, Sichuan University, West China Hospital, Chengdu, China, 2Chinese Evidence-Based Medicine/Cochrane Center, Chengdu,China,3DepartmentofOncology,StateKeyLaboratoryofBiotherapyandCancerCenter,WestChinaMedicalSchool,SichuanUniversity,WestChinaHospital, Chengdu,China,4DepartmentofOrthopedics,SichuanUniversity,WestChinaHospital,Chengdu,China Abstract BackgroundandObjective:Emergingevidencefrombiologicalandepidemiologicalstudieshassuggestedthatbodyiron storesandheme-ironintakemayberelatedtotheriskoftype2diabetes(T2D).Weaimedtoexaminetheassociationof body iron stores andheme-iron intake withT2D risk by conducting asystematicreview andmeta-analysis of previously publishedstudies. ResearchDesignandMethods:Systematicreviewandsubsequentmeta-analysiswereconductedbysearchingMEDLINE database up to June 22, 2012 to identify studies that analyzed the association of body iron stores or dietary heme-iron intake with T2D risk. The meta-analysis was performed using the effect estimates and 95% confidence intervals (CIs) to calculatethepooledriskestimates,whiletheheterogeneityamongstudieswasexaminedusingtheI2andQstatistic. Results: The meta-analysis included 16 high-quality studies: 12 studies analyzed ferritin levels (4,366 T2D patients and 41,091controls)and4measuredheme-ironintake(9,246T2Dpatientsand179,689controls).Thecombinedrelativerisk(RR) comparingthehighestandlowestcategoryofferritinlevelswas1.66(95%CI:1.15–2.39)forprospectivestudies,2.29(95% CI:1.48–3.54)forcross-sectionalstudieswithheterogeneity(Q=14.84,p=0.01,I2=66.3%;Q=44.16,p,0.001,I2 =88.7%). The combined RR comparing the highest and lowest category of heme-iron intake was 1.31 (95% CI: 1.21–1.43) with heterogeneity(Q=1.39,p=0.71,I2=0%).Nopublicationbiaswasfound.Additional15studiesthatwereofgoodq