Breast Cancer Affects Both the Hippocampus Volume and the Episodic Autobiographical Memory Retrieval 英文参考文献.docVIP

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Breast Cancer Affects Both the Hippocampus Volume and the Episodic Autobiographical Memory Retrieval 英文参考文献.doc

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Breast Cancer Affects Both the Hippocampus Volume and the Episodic Autobiographical Memory Retrieval 英文参考文献

BreastCancerAffectsBoththeHippocampusVolume andtheEpisodicAutobiographicalMemoryRetrieval LoretxuBergouignan1,2,3*,JeanPierreLefranc4,MarieChupin5,NastassjaMorel1,6,JeanPhilippe Spano7,PhilippeFossati1,8 1CNRS USR 3246, CR-ICM, Pitie′-Salpe?trie`re Hospital, Paris, France, 2Brain, Body and Self Laboratory, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden, 3Center for NeuroImaging Research, Pitie′-Salpe?trie`re Hospital, Paris, France, 4Department of Gynecologic Surgery, Pitie′-Salpe?trie`re Hospital, Assistance PubliqueHo?pitauxdeParis,Paris,France,5CenterforResearchoftheInstituteoftheBrainandoftheSpinalCord,Universite′PierreetMarieCurie-Paris,UMRS875,Inserm U975,CNRS7225,Paris,France,6CognitiveNeuropsychologyandFunctionalNeuroanatomyofHumanMemory,UMRS923INSERM,CaenBasse-NormandieUniversity/ EPHE/INSERM, Caen, France, 7Department of Medical Oncology, Pitie′-Salpe?trie`re Hospital, Assistance Publique-Ho?pitaux de Paris, Paris, France, 8Department of Psychiatry,Pitie′-Salpe?trie`re Hospital,AssistancePublique-Ho?pitauxdeParis,Universite′ PierreetMarieCurie,Paris,France Abstract Background: Neuroimaging studies show the hippocampus is a crucial node in the neural network supporting episodic autobiographicalmemoryretrieval.Stress-relatedpsychiatricdisorders,namelyMajorDepressionandPostTraumaticStress Disorder (PTSD), are related to reduced hippocampus volume. However, this is not the case for remitted breast cancer patientswithco-morbidstress-relatedpsychiatricdisorders.Thisexceptionmaybeduetothefactthat,consequentlytothe cancer experience as such, this population might already be characterized by a reduced hippocampus with an episodic autobiographicalmemorydeficit. Methodology:Wescanned,witha3TSiemensTRIO,16patientswhohadlivedthrougha‘‘standardexperienceofbreast cancer’’ (breast cancer and a standard treatment in remission since 18 month) in the absence of any associated stress- related psychiatric or neurological disorder and 21 matched contro